About

This medication is a dual-combination oral antidiabetic agent indicated for the management of type 2 diabetes mellitus in adults. It combines dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, with a dipeptidyl peptidase-4 (DPP-4) inhibitor. Dapagliflozin works by inhibiting SGLT2 in the kidneys, leading to increased urinary glucose excretion and a reduction in blood glucose levels. The DPP-4 inhibitor enhances the body's natural ability to control blood sugar by preventing the breakdown of incretin hormones, which stimulate insulin release in a glucose-dependent manner and suppress glucagon secretion. This complementary mechanism of action helps to improve glycemic control through both insulin-dependent and insulin-independent pathways.

Uses

Treatment of type 2 diabetes mellitus.
As an adjunct to diet and exercise.
To improve glycemic control.
When monotherapy is insufficient.

Directions For Use

Take orally once daily, preferably in the morning, with or without food, as advised by your doctor.

Benefits

Effective reduction in HbA1c.
Supports weight reduction.
Offers cardiovascular benefits.
Provides renal protective effects.
Low risk of hypoglycemia.
Improves post-meal glucose levels.

Side Effects

Genital yeast infections
Urinary tract infections
Increased urination
Headache
Nasopharyngitis
Upper respiratory tract infection
Dizziness
Back pain
Fatigue
Diarrhea
Rash
Rarely, pancreatitis

Safety Measures

Alcohol - Limit alcohol intake as it may increase the risk of dehydration and, rarely, ketoacidosis.
Pregnancy - Not recommended during pregnancy; consult your doctor for appropriate management.
Breastfeeding - Avoid during breastfeeding as components may be excreted in breast milk; seek medical advice.
Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
Kidney - Contraindicated in severe renal impairment; dose adjustment required for moderate impairment.
Lung - Generally safe, but monitor for any unusual respiratory symptoms.

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