DAPAHENZ SM 1000 TAB 10 S

About

Dapahenz SM 1000 Tab is a combination medication containing Dapagliflozin and Metformin (likely sustained-release). Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by blocking glucose reabsorption in the kidneys, leading to increased glucose excretion in the urine and reduced blood glucose levels. Metformin, a biguanide, primarily reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. This dual mechanism of action provides comprehensive glycemic control for patients with type 2 diabetes.

The combination of Dapagliflozin and Metformin offers synergistic benefits, addressing different pathophysiological pathways of type 2 diabetes. It not only helps in achieving better glycemic targets but also leverages the cardiovascular and renal protective effects of Dapagliflozin, alongside Metformin's established efficacy and safety profile. This makes it a valuable option for patients who require more intensive glucose management or who have comorbidities that benefit from the specific actions of these agents.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control in adults.
• Reduction of cardiovascular risk in type 2 diabetes patients.
• Used as an adjunct to diet and exercise.

Directions For Use

Take orally, usually once or twice daily with meals, as prescribed by your doctor. Swallow the tablet whole.

Benefits

• Provides comprehensive blood glucose control.
• Reduces hepatic glucose production.
• Improves insulin sensitivity.
• Offers cardiovascular and renal protection.
• May contribute to modest weight loss.
• Convenience of a single tablet combination.

Side Effects

• Urinary tract infections (UTIs)
• Genital yeast infections
• Diarrhea
• Nausea and vomiting
• Abdominal discomfort
• Increased urination
• Thirst
• Dizziness
• Hypoglycemia (when used with other agents)
• Lactic acidosis (rare, Metformin-related)
• Vitamin B12 deficiency (long-term Metformin use)
• Ketoacidosis (rare, Dapagliflozin-related)

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of lactic acidosis (due to Metformin) and ketoacidosis (due to Dapagliflozin).
• Pregnancy - Generally not recommended during pregnancy, especially in the second and third trimesters. Consult a doctor to discuss alternatives.
• Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk. Consult a doctor.
• Liver - Use with caution in patients with liver impairment; Metformin is contraindicated in severe hepatic dysfunction due to increased risk of lactic acidosis.
• Kidney - Contraindicated in severe kidney impairment (eGFR below a certain threshold) due to Metformin's risk of lactic acidosis and reduced efficacy of Dapagliflozin.
• Lung - Generally safe for use in patients with lung conditions; however, conditions causing hypoxia may increase lactic acidosis risk with Metformin.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.