SPIKERID TRIO 10S

About

SPIKERID TRIO is a triple-combination oral antidiabetic medication designed for the comprehensive management of Type 2 Diabetes Mellitus. It typically combines a biguanide (like Metformin), a sulfonylurea (like Glimepiride), and a DPP-4 inhibitor (like Teneligliptin or Vildagliptin). Metformin reduces hepatic glucose production and improves insulin sensitivity. Glimepiride stimulates insulin secretion from pancreatic beta cells. The DPP-4 inhibitor enhances incretin hormone levels, leading to glucose-dependent insulin release and reduced glucagon secretion. This multi-pronged approach targets various pathophysiological defects in Type 2 Diabetes, providing robust glycemic control. It is indicated for patients who have not achieved adequate blood sugar control with dual therapy or who require a more intensive regimen. The combination aims to significantly lower HbA1c, reduce post-prandial and fasting glucose levels, and minimize the risk of diabetes-related complications.

Uses

• Intensive management of Type 2 Diabetes Mellitus
• To achieve optimal glycemic control
• As an adjunct to diet and exercise
• When dual therapy is insufficient

Directions For Use

Take this medication orally, usually once or twice daily with meals, or as directed by your physician. Swallow the tablet whole with water.

Benefits

• Comprehensive blood sugar control
• Significant HbA1c reduction
• Triple mechanism of action
• Improved insulin secretion and sensitivity
• Reduced risk of diabetic complications
• Convenient multi-drug therapy

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Diarrhea
• Abdominal discomfort
• Headache
• Dizziness
• Upper respiratory tract infection
• Pancreatitis (rare)
• Joint pain
• Metallic taste
• Lactic acidosis (rare but serious)
• Weight gain (variable)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to increased risk of hypoglycemia and lactic acidosis, especially with metformin.
• Pregnancy - Generally not recommended during pregnancy. Consult your doctor; insulin is often preferred for glycemic control.
• Breastfeeding - Not advised during breastfeeding as components may pass into breast milk. Consult your doctor.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary. Contraindicated in severe hepatic failure.
• Kidney - Use with caution and dose adjustment in patients with kidney impairment. Contraindicated in severe renal failure due to metformin accumulation risk.
• Lung - No specific contraindication for lung conditions, but severe respiratory insufficiency may increase lactic acidosis risk.

Disclaimer

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