SITALEMBIC MD 500 TAB 15'S

About

SITALEMBIC MD 500 TAB is a combination medication designed for the comprehensive management of type 2 diabetes mellitus. It contains Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin, a biguanide. Sitagliptin works by enhancing the body's natural ability to lower elevated blood sugar levels. It achieves this by increasing the active levels of incretin hormones, such as GLP-1 and GIP, which are released in response to food intake. These hormones stimulate insulin release from pancreatic beta cells and reduce glucagon secretion from alpha cells in a glucose-dependent manner.

Metformin, on the other hand, primarily acts by reducing glucose production in the liver and improving insulin sensitivity in peripheral tissues, allowing the body's cells to utilize glucose more effectively. This dual mechanism of action provides robust glycemic control, making it an effective adjunct to diet and exercise for adults whose blood sugar is not adequately controlled by either monotherapy. The combination helps to achieve target HbA1c levels and manage post-prandial glucose excursions.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control.
• Used as an adjunct to diet and exercise.
• When monotherapy is insufficient.

Directions For Use

Take this medication orally, usually once or twice daily with meals, as prescribed by your doctor.

Benefits

• Effective blood sugar reduction.
• Improved insulin sensitivity.
• Reduced hepatic glucose production.
• Lowered HbA1c levels.
• Generally well-tolerated.
• Convenient combination therapy.

Side Effects

• Nausea
• Diarrhea
• Vomiting
• Abdominal discomfort
• Headache
• Upper respiratory tract infection
• Sore throat
• Nasal congestion
• Hypoglycemia (less common than sulfonylureas)
• Lactic acidosis (rare, serious)
• Joint pain
• Pancreatitis (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of lactic acidosis, especially with metformin.
• Pregnancy - Generally not recommended during pregnancy unless clearly necessary; consult a doctor.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk; consult a doctor.
• Liver - Use with caution in patients with liver impairment; dose adjustment or avoidance may be necessary.
• Kidney - Contraindicated in severe renal impairment due to metformin accumulation risk; dose adjustment needed for moderate impairment.
• Lung - No specific contraindications, but severe respiratory conditions increasing hypoxia risk may increase lactic acidosis risk.

Disclaimer

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