About
Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by reducing glucose reabsorption in the kidneys, leading to increased glucose excretion in the urine and subsequently lowering blood glucose levels. Metformin, a biguanide, acts primarily by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues. This combination therapy, Empashield M, offers a comprehensive approach to managing type 2 diabetes by addressing both insulin resistance and glucose overproduction. It is particularly beneficial for adults who require improved glycemic control and for those with established cardiovascular disease or chronic kidney disease, as empagliflozin has demonstrated significant benefits in reducing the risk of major adverse cardiovascular events and slowing the progression of kidney disease. The synergistic action of these two agents helps achieve robust blood sugar reduction and provides additional protective effects.
Uses
- Management of type 2 diabetes mellitus.
- To improve glycemic control in adults.
- To reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.
- To reduce the risk of hospitalization for heart failure in adults with type 2 diabetes.
Directions For Use
Take orally with food, usually twice daily, or as prescribed by your doctor.
Benefits
- Effective blood sugar control.
- Reduced HbA1c levels.
- Potential for weight loss.
- Lowered risk of cardiovascular events.
- Improved kidney outcomes.
- Enhanced insulin sensitivity.
Side Effects
- Nausea
- Diarrhea
- Vomiting
- Abdominal discomfort
- Urinary tract infections
- Genital yeast infections
- Increased urination
- Thirst
- Hypoglycemia (when used with insulin or sulfonylureas)
- Dizziness
- Fatigue
- Rarely, lactic acidosis
Safety Measures
- Alcohol - Avoid excessive alcohol intake as it can increase the risk of lactic acidosis with metformin and may increase the risk of hypoglycemia.
- Pregnancy - Generally not recommended during pregnancy, especially in the second and third trimesters. Consult your doctor.
- Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk. Consult your doctor.
- Liver - Use with caution in patients with liver impairment; metformin is contraindicated in severe hepatic dysfunction due to increased risk of lactic acidosis.
- Kidney - Contraindicated in severe renal impairment. Dose adjustment is necessary for moderate renal impairment.
- Lung - Generally safe, but caution is advised in patients with severe acute respiratory failure due to increased risk of lactic acidosis with metformin.
Disclaimer
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