EMPASHILD S 10/100 10S

About

EMPASHILD S 10/100 is a combination medication containing Empagliflozin 10mg and Sitagliptin 100mg, formulated for the effective management of type 2 diabetes mellitus. Empagliflozin, an SGLT2 inhibitor, acts by preventing the kidneys from reabsorbing glucose, leading to its excretion in the urine and a subsequent reduction in blood glucose levels. Sitagliptin, a DPP-4 inhibitor, works by enhancing the body's own ability to lower elevated blood sugar by increasing the active levels of incretin hormones, which promote glucose-dependent insulin release and suppress glucagon secretion. This synergistic approach not only provides robust glycemic control but also offers additional benefits such as weight management and cardiovascular protection, making it a valuable option for patients requiring comprehensive diabetes care.

Uses

• To improve glycemic control in adults with type 2 diabetes mellitus.
• Used as an adjunct to diet and exercise.
• For patients inadequately controlled on empagliflozin or sitagliptin alone.
• May reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.

Directions For Use

Take this medication orally, usually once daily in the morning, with or without food, as prescribed by your healthcare provider. Swallow the tablet whole with water.

Benefits

• Effective blood glucose control through two distinct mechanisms.
• Significant reduction in HbA1c levels.
• Potential for modest weight loss.
• May offer cardiovascular and renal protective benefits.
• Low risk of hypoglycemia when used alone.
• Improved insulin secretion and reduced glucose reabsorption.

Side Effects

• Urinary tract infections
• Genital yeast infections
• Increased urination
• Nausea
• Headache
• Nasopharyngitis
• Diarrhea
• Joint pain
• Dizziness
• Hypoglycemia (when used with insulin or sulfonylureas)
• Dehydration
• Pancreatitis (rare)

Safety Measures

• Alcohol - Limit alcohol intake as it can increase the risk of dehydration and may also increase the risk of hypoglycemia, especially with empagliflozin.
• Pregnancy - Not recommended during pregnancy, especially in the second and third trimesters, due to potential adverse effects on fetal kidney development. Consult your doctor.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and could affect the infant. Consult your doctor.
• Liver - Generally no dose adjustment needed for either component, but use with caution in severe hepatic impairment.
• Kidney - Empagliflozin efficacy is reduced with declining eGFR and is not recommended below certain eGFR levels. Sitagliptin requires dose adjustment for moderate to severe renal impairment.
• Lung - No specific contraindication for lung conditions, but monitor for signs of respiratory infection.

Disclaimer

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