Endoxan N 500mg Injection

About

Endoxan N 500mg Injection contains Cyclophosphamide, an alkylating antineoplastic agent that interferes with DNA replication and transcription, leading to cell death. It is a prodrug that requires metabolic activation in the liver to its active forms, phosphoramide mustard and acrolein. These active metabolites cross-link DNA strands, preventing cell division and growth, making it effective against rapidly proliferating cells, such as cancer cells.

Beyond its use in various cancers, cyclophosphamide also possesses significant immunosuppressive properties, making it valuable in the treatment of severe autoimmune diseases. Its broad spectrum of activity necessitates careful dosing and monitoring due to its potential for serious side effects, including myelosuppression and hemorrhagic cystitis. Administration is typically intravenous, under strict medical supervision, as part of a comprehensive treatment plan.

Uses

• Treatment of various types of cancer (e.g., lymphoma, leukemia, breast cancer).
• Management of severe autoimmune diseases (e.g., lupus, vasculitis).
• Conditioning regimen for bone marrow transplantation.
• Treatment of nephrotic syndrome.

Directions For Use

Administer intravenously under the supervision of a qualified healthcare professional. Dosage and schedule are highly individualized based on condition and patient response.

Benefits

• Effective against a wide range of cancers.
• Potent immunosuppressive agent for autoimmune diseases.
• Can induce remission in severe conditions.
• Part of established chemotherapy regimens.
• Used in life-saving transplant procedures.
• Helps control disease progression.

Side Effects

• Nausea and vomiting (severe)
• Hair loss (alopecia)
• Myelosuppression (low blood counts)
• Hemorrhagic cystitis
• Infections
• Fatigue
• Mouth sores (mucositis)
• Infertility
• Cardiotoxicity (high doses)
• Secondary malignancies (long-term risk)
• Anorexia
• Skin and nail changes

Safety Measures

• Alcohol - Alcohol should be avoided or consumed with extreme caution due to potential liver toxicity and exacerbation of side effects like nausea.
• Pregnancy - Cyclophosphamide is highly teratogenic and embryotoxic. It is contraindicated during pregnancy due to severe risk of fetal harm.
• Breastfeeding - Cyclophosphamide is excreted into breast milk and can cause serious adverse effects in the infant. Breastfeeding is contraindicated during treatment.
• Liver - Cyclophosphamide is a prodrug activated by the liver. Dose adjustments may be necessary in patients with severe liver impairment.
• Kidney - Cyclophosphamide and its metabolites are primarily excreted by the kidneys. Dose reduction is often required in patients with renal impairment to prevent toxicity.
• Lung - Cyclophosphamide can cause pulmonary toxicity, including interstitial pneumonitis and pulmonary fibrosis, especially with prolonged use or high doses. Close monitoring is essential.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.