ETERNEX M 500 10 S

About

ETERNEX M 500 contains Metformin hydrochloride, an oral biguanide antidiabetic agent used for the management of type 2 diabetes mellitus. It works primarily by decreasing glucose production by the liver (hepatic gluconeogenesis), reducing the absorption of glucose from the intestines, and improving insulin sensitivity in peripheral tissues. By enhancing the body's response to its own insulin, Metformin helps to lower both fasting and postprandial blood glucose levels. It is often prescribed as a first-line treatment for type 2 diabetes, particularly in overweight and obese patients, as it is associated with weight neutrality or modest weight loss. Metformin does not typically cause hypoglycemia when used alone, making it a safe and effective option for long-term glycemic control when combined with diet and exercise.

Uses

• Treatment of type 2 diabetes mellitus.
• Improvement of glycemic control in adults and children (10 years and older).
• Used as an adjunct to diet and exercise.
• Management of polycystic ovary syndrome (off-label).

Directions For Use

Take orally, usually once or twice daily, with meals to reduce gastrointestinal side effects, or as advised by your physician.

Benefits

• Effective blood glucose lowering.
• Improved insulin sensitivity.
• Reduced hepatic glucose production.
• Potential for weight neutrality or modest weight loss.
• Low risk of hypoglycemia when used alone.
• Cardiovascular benefits in some diabetic patients.

Side Effects

• Nausea
• Diarrhea
• Abdominal discomfort
• Vomiting
• Metallic taste in mouth
• Loss of appetite
• Headache
• Dizziness
• Vitamin B12 deficiency (with long-term use)
• Skin rash
• Fatigue
• Lactic acidosis (rare but serious)

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it significantly increases the risk of lactic acidosis, a rare but severe complication. Alcohol can also potentiate hypoglycemia.
• Pregnancy - Generally not recommended during pregnancy. Consult your doctor to discuss the risks and benefits, and consider insulin therapy if needed.
• Breastfeeding - Metformin is excreted in breast milk in small amounts. Consult your doctor to assess the potential risks to the infant versus the benefits of treatment.
• Liver - Contraindicated in severe hepatic impairment due to an increased risk of lactic acidosis. Use with caution in patients with any liver disease.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment is necessary for moderate renal impairment.
• Lung - Generally considered safe for use in patients with lung conditions. No specific contraindications related to pulmonary function.

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