Farmorubicin RTU 10mg Injection

About

Farmorubicin RTU 10mg Injection contains Epirubicin, an anthracycline topoisomerase II inhibitor, widely used in the treatment of various cancers. It is indicated for breast cancer, ovarian cancer, gastric cancer, and small cell lung cancer, among others. Epirubicin exerts its cytotoxic effects by intercalating into DNA, inhibiting topoisomerase II, and generating free radicals, all of which lead to DNA damage and inhibition of nucleic acid synthesis. This multi-modal action disrupts cancer cell proliferation and induces apoptosis.

As a ready-to-use formulation, it simplifies preparation and administration. Epirubicin is a key component in many chemotherapy regimens, particularly in adjuvant and neoadjuvant settings for breast cancer. Its efficacy is balanced by potential toxicities, notably cardiotoxicity and myelosuppression, which necessitate careful patient monitoring throughout the treatment course.

Uses

• Adjuvant treatment of breast cancer.
• Treatment of advanced breast cancer.
• Management of ovarian cancer.
• Treatment of gastric cancer.

Directions For Use

Administered intravenously by a qualified healthcare professional. Strict monitoring during infusion is essential.Benefits

• Broad-spectrum anticancer activity.
• Effective in various solid tumors.
• Key component in breast cancer regimens.
• Ready-to-use formulation for convenience.
• Induces DNA damage and apoptosis in cancer cells.
• Well-established clinical efficacy.

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Alopecia (hair loss)
• Mucositis/stomatitis
• Cardiotoxicity (dose-dependent)
• Fatigue
• Diarrhea
• Red urine (harmless, due to drug color)
• Injection site reactions
• Fever
• Anorexia
• Amenorrhea

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased gastrointestinal irritation and liver strain.
• Pregnancy - Contraindicated; highly teratogenic. Women of childbearing potential must use effective contraception.
• Breastfeeding - Contraindicated; may cause serious adverse effects in the infant.
• Liver - Dose adjustment required for hepatic impairment; monitor liver function closely.
• Kidney - No specific dose adjustment required for mild to moderate renal impairment. Use with caution in severe impairment.
• Lung - Monitor for pulmonary toxicity, though less common than with other anthracyclines.

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