Faslodex 250mg Injection

About

Faslodex 250mg Injection contains fulvestrant, an estrogen receptor antagonist that works by selectively binding to and degrading the estrogen receptor (ER) in breast cancer cells. This mechanism of action differs from traditional selective estrogen receptor modulators (SERMs) as fulvestrant causes a downregulation of the ER protein, effectively blocking estrogen's ability to stimulate cancer cell growth. It is primarily used in hormone receptor-positive breast cancer, particularly in postmenopausal women, or in men with advanced breast cancer, who have progressed on prior endocrine therapy. By reducing the number of estrogen receptors, Faslodex helps to inhibit the proliferation of ER-positive breast cancer cells, offering a crucial therapeutic option for patients whose tumors rely on estrogen for growth.

This targeted approach helps to overcome resistance mechanisms that can develop with other endocrine therapies, providing a valuable second-line or later-line treatment. It is administered via intramuscular injection, ensuring sustained therapeutic levels.

Uses

• Treatment of hormone receptor-positive advanced breast cancer in postmenopausal women.
• Used after progression on prior endocrine therapy.
• Can be used in combination with other targeted therapies for breast cancer.
• Management of advanced breast cancer in men.

Directions For Use

Faslodex 250mg Injection is administered as an intramuscular injection into the buttock by a healthcare professional. The usual dose is 500mg (two 250mg injections) once a month, with an additional dose two weeks after the first.

Benefits

• Targets estrogen receptors directly.
• Effective in hormone receptor-positive breast cancer.
• Can be used after other endocrine therapies fail.
• Administered monthly, offering convenience.
• May improve progression-free survival.
• Offers a non-chemotherapeutic option.

Side Effects

• Injection site pain
• Nausea
• Fatigue
• Hot flashes
• Headache
• Back pain
• Joint pain
• Vomiting
• Anorexia
• Constipation
• Diarrhea
• Elevated liver enzymes

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol consumption should be avoided, especially if liver function is compromised.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Women of childbearing potential must use effective contraception during and for a period after treatment.
• Breastfeeding - Breastfeeding is not recommended during treatment with Faslodex due to potential excretion into breast milk and harm to the infant.
• Liver - Use with caution in patients with moderate to severe hepatic impairment; dose adjustments may be necessary, and liver function should be closely monitored.
• Kidney - Use with caution in patients with severe renal impairment (creatinine clearance <30 mL/min); no dose adjustment is generally needed for mild to moderate impairment.
• Lung - No specific contraindications related to lung conditions, but monitor for any new or worsening respiratory symptoms.

Disclaimer

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