FPGLI M2 TAB 10 S

About

FPGLI M2 TAB is a sophisticated combination medication designed for the comprehensive management of type 2 diabetes mellitus, integrating a dipeptidyl peptidase-4 (DPP-4) inhibitor (such as sitagliptin) with metformin hydrochloride. The DPP-4 inhibitor component functions by preserving the activity of incretin hormones, such as GLP-1 and GIP, which are naturally released by the intestine in response to food intake. These hormones stimulate insulin secretion from pancreatic beta cells and suppress glucagon release from alpha cells in a glucose-dependent manner, thereby improving glycemic control. Metformin, a well-established biguanide, complements this action by primarily reducing glucose production in the liver, decreasing glucose absorption from the gastrointestinal tract, and enhancing insulin sensitivity in peripheral tissues. This synergistic dual mechanism addresses multiple pathophysiological defects in type 2 diabetes, leading to significant reductions in both fasting and post-meal blood glucose levels and overall HbA1c. It is particularly beneficial when monotherapy with either agent is insufficient, offering a robust approach to achieving optimal glycemic targets.

Uses

• Treatment of type 2 diabetes mellitus.
• As an adjunct to diet and exercise.
• When monotherapy with metformin or a DPP-4 inhibitor is inadequate.
• To improve glycemic control in adults.

Directions For Use

Take with meals to reduce gastrointestinal side effects, usually twice daily, or as directed by your physician. Swallow tablets whole.

Benefits

• Provides dual mechanism for blood glucose control.
• Effectively lowers HbA1c levels.
• Reduces post-meal glucose spikes.
• Low risk of hypoglycemia when used alone.
• May lead to modest weight loss (due to metformin).
• Convenient fixed-dose combination.

Side Effects

• Nausea.
• Diarrhea.
• Abdominal pain.
• Headache.
• Upper respiratory tract infection.
• Sore throat.
• Nasal congestion.
• Joint pain.
• Pancreatitis (rare).
• Lactic acidosis (rare, due to metformin).
• Vitamin B12 deficiency (with long-term metformin use).
• Allergic reactions (rash, hives).

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of lactic acidosis, a rare but serious side effect of metformin.
• Pregnancy - Not recommended during pregnancy; consult a doctor to discuss alternative treatments for gestational diabetes or pre-existing diabetes.
• Breastfeeding - Both components may pass into breast milk; not recommended during breastfeeding. Consult a healthcare professional.
• Liver - Use with caution in patients with liver impairment; metformin is contraindicated in severe liver disease due to increased risk of lactic acidosis.
• Kidney - Metformin is contraindicated in severe kidney impairment (eGFR <30 mL/min/1.73m²); dose adjustment is required for moderate impairment.
• Lung - No specific lung-related contraindications; however, ensure overall health status is monitored.

Disclaimer

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