GLENZA 40 MG CAPS 14'S

About

Enzalutamide is a potent androgen receptor inhibitor that acts through a multi-faceted mechanism to disrupt the androgen receptor signaling pathway, which is critical for prostate cancer cell growth and survival. It competitively inhibits androgen binding to androgen receptors, preventing their activation. Furthermore, it inhibits androgen receptor nuclear translocation, thereby blocking the movement of the activated receptor into the cell nucleus. Lastly, it impairs DNA binding and transcription of androgen receptor-regulated genes, effectively shutting down the genetic programs that drive cancer progression. This comprehensive inhibition leads to decreased proliferation and increased apoptosis of prostate cancer cells. Enzalutamide is a cornerstone in the treatment of metastatic castration-resistant prostate cancer (mCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC), significantly improving overall survival and progression-free survival in these patient populations by effectively suppressing androgen signaling.

Uses

• Metastatic castration-resistant prostate cancer (mCRPC)
• Non-metastatic castration-resistant prostate cancer (nmCRPC)
• Metastatic hormone-sensitive prostate cancer (mHSPC)
• Prostate cancer progression

Directions For Use

Take orally once daily with or without food, as prescribed by your oncologist.

Benefits

• Inhibits androgen receptor signaling
• Slows prostate cancer progression
• Improves overall survival
• Delays chemotherapy initiation
• Oral administration
• Effective in castration-resistant disease

Side Effects

• Asthenia/fatigue
• Hot flashes
• Hypertension
• Diarrhea
• Headache
• Back pain
• Arthralgia
• Peripheral edema
• Nausea
• Seizures (rare)
• Falls
• Fractures

Safety Measures

• Alcohol - No specific contraindication, but avoid excessive alcohol.
• Pregnancy - Contraindicated in women who are or may become pregnant.
• Breastfeeding - Not applicable for male patients. Women should not breastfeed.
• Liver - Use with caution; monitor liver function. Dose adjustment may be needed for severe impairment.
• Kidney - Use with caution; monitor renal function. Dose adjustment may be needed for severe impairment.
• Lung - No specific precautions for lung conditions.

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