GLENZA 80MG CAPSULE

About

Enzalutamide is a potent androgen receptor inhibitor specifically developed for the treatment of prostate cancer, including both metastatic and non-metastatic castration-resistant forms. Its unique mechanism of action involves binding directly to the androgen receptor, thereby inhibiting several critical steps in the androgen receptor signaling pathway. These steps include preventing androgen binding, inhibiting androgen receptor nuclear translocation, blocking DNA binding, and ultimately impairing gene transcription. This comprehensive, multi-step inhibition effectively prevents the growth and survival of prostate cancer cells that are dependent on androgen signaling for proliferation. By disrupting this crucial pathway, enzalutamide has demonstrated significant improvements in overall survival and radiographic progression-free survival in patients, offering a vital therapeutic option for advanced prostate cancer, even after failure of traditional androgen deprivation therapies.

Uses

• Treatment of metastatic castration-resistant prostate cancer (mCRPC).
• Treatment of non-metastatic castration-resistant prostate cancer (nmCRPC).
• Used in patients who have failed prior androgen deprivation therapy.
• Management of advanced prostate cancer.

Directions For Use

Take this capsule orally, once daily, with or without food, as prescribed by your doctor. Swallow the capsules whole.

Benefits

• Effective in castration-resistant prostate cancer.
• Improves overall survival in mCRPC.
• Delays disease progression in nmCRPC.
• Oral administration offers convenience.
• Targets multiple steps of androgen receptor signaling.
• Can be used before or after chemotherapy.

Side Effects

• Fatigue
• Hot flashes
• Headache
• Hypertension (high blood pressure)
• Diarrhea
• Nausea
• Decreased appetite
• Arthralgia (joint pain)
• Peripheral edema
• Seizures (rare but serious)
• Falls
• Fractures

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may increase the risk of certain side effects like fatigue or liver enzyme elevation.
• Pregnancy - Enzalutamide is not indicated for use in women. It can cause fetal harm if administered to a pregnant woman. Men treated with enzalutamide should use effective contraception if their partner is pregnant or of childbearing potential.
• Breastfeeding - Enzalutamide is not indicated for use in women. It is unknown if it is excreted in human milk.
• Liver - Use with caution in patients with severe hepatic impairment. Dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Use with caution in patients with severe renal impairment. No specific dose adjustment is usually required, but monitor for adverse effects.
• Lung - No specific lung-related safety concerns are commonly associated with Enzalutamide.

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