GLYCINORM 160

About

Gliclazide is an oral hypoglycemic agent belonging to the sulfonylurea class, primarily used in the management of type 2 diabetes mellitus in adults. Its main mechanism of action involves stimulating the beta cells of the pancreas to release insulin, thereby lowering elevated blood glucose levels. This insulinotropic effect is glucose-dependent, meaning it is more pronounced when blood glucose concentrations are high, which helps to reduce the risk of severe hypoglycemia. Gliclazide also contributes to improved peripheral insulin sensitivity and a reduction in hepatic glucose production, enhancing the body's overall ability to manage glucose. It is typically prescribed when diet, exercise, and weight reduction alone are insufficient to achieve adequate glycemic control. By effectively managing blood sugar, Gliclazide helps to prevent or delay the progression of long-term microvascular and macrovascular complications associated with uncontrolled diabetes, such as neuropathy, retinopathy, and cardiovascular disease, thereby improving patient outcomes and quality of life.

Uses

• Management of type 2 diabetes mellitus.
• To lower high blood sugar levels.
• Used when diet and exercise are insufficient.
• As part of a comprehensive diabetes management plan.

Directions For Use

Take orally with food, preferably with breakfast or the first main meal of the day, as directed by your physician.

Benefits

• Effectively lowers blood glucose levels.
• Stimulates insulin secretion from the pancreas.
• Helps achieve better glycemic control.
• Reduces the risk of diabetes-related complications.
• Convenient once-daily dosing for some formulations.
• Improves overall metabolic health in type 2 diabetes.

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Diarrhea
• Constipation
• Abdominal pain
• Headache
• Dizziness
• Skin rash
• Pruritus (itching)
• Weight gain
• Allergic reactions
• Liver enzyme elevation

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and may interfere with blood sugar control.
• Pregnancy - Generally not recommended during pregnancy. Insulin therapy is usually preferred for glycemic control in pregnant women with diabetes.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and cause hypoglycemia in the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary due to altered metabolism and increased risk of hypoglycemia.
• Kidney - Use with caution in patients with kidney impairment; dose adjustment may be necessary to prevent accumulation and increased risk of hypoglycemia.
• Lung - No specific direct contraindications related to lung conditions, but general caution applies in severely ill patients.

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