GLZ XR TAB 15 S

About

GLZ XR TAB contains Gliclazide, an oral hypoglycemic agent classified as a second-generation sulfonylurea. This extended-release formulation is specifically designed for the sustained management of type 2 diabetes mellitus. Gliclazide primarily works by stimulating the release of insulin from the pancreatic beta cells. It achieves this by binding to specific sulfonylurea receptors on the beta-cell membrane, which leads to the closure of ATP-sensitive potassium channels. This closure causes depolarization of the beta-cell membrane, triggering an influx of calcium ions, which in turn stimulates the exocytosis of insulin granules.

The extended-release nature of GLZ XR ensures a gradual and prolonged release of the active ingredient, providing consistent blood glucose control throughout the day and minimizing fluctuations. It is used as an adjunct to diet and exercise when these lifestyle interventions alone are insufficient to achieve adequate glycemic control.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control.
• Used as an adjunct to diet and exercise.
• When other therapies are inadequate.

Directions For Use

Take this medication orally once daily, preferably with breakfast, as directed by your physician.

Benefits

• Effective blood sugar lowering.
• Sustained glycemic control with XR formulation.
• Reduced HbA1c levels.
• Improved insulin secretion.
• Cardiovascular benefits (some studies).
• Convenient once-daily dosing.

Side Effects

• Hypoglycemia (most common)
• Nausea
• Diarrhea
• Abdominal pain
• Constipation
• Headache
• Dizziness
• Skin rash
• Pruritus
• Weight gain
• Liver enzyme elevation (rare)
• Blood dyscrasias (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of hypoglycemia and may cause a disulfiram-like reaction.
• Pregnancy - Not recommended during pregnancy due to potential for fetal hypoglycemia; insulin is generally preferred.
• Breastfeeding - Not recommended during breastfeeding as it may be excreted in breast milk and cause hypoglycemia in the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary due to increased risk of hypoglycemia.
• Kidney - Use with caution in patients with renal impairment; dose adjustment may be necessary to avoid accumulation and hypoglycemia.
• Lung - No specific contraindications or safety notes related to lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.