About
This medication is a combination therapy for Type 2 Diabetes Mellitus, integrating a sulfonylurea, gliclazide, with a biguanide, metformin. Gliclazide primarily functions by stimulating the beta cells in the pancreas to release more insulin, thereby lowering blood glucose levels. Metformin, on the other hand, works through multiple mechanisms: it significantly reduces glucose production in the liver, decreases the absorption of glucose from the intestines, and importantly, enhances the body's sensitivity to insulin, allowing cells to utilize glucose more effectively. This dual action provides a comprehensive and complementary approach to managing hyperglycemia, aiming to improve overall glycemic control in adult patients whose blood sugar levels are not adequately managed by diet and exercise alone, or by monotherapy with either agent. The synergistic effect of these two agents helps to achieve better therapeutic outcomes and reduce the risk of long-term diabetic complications.
Uses
- Management of Type 2 Diabetes Mellitus.
- To improve blood sugar control.
- When diet and exercise are not enough.
- As an adjunct to lifestyle modifications.
Directions For Use
Take orally with meals as directed by your physician. Do not crush or chew the tablets.
Benefits
- Effective blood glucose reduction.
- Dual mechanism of action.
- Improved insulin sensitivity.
- Reduced risk of long-term diabetic complications.
- May help with weight management (metformin).
- Convenient combination therapy.
Side Effects
- Hypoglycemia (low blood sugar)
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Metallic taste
- Headache
- Dizziness
- Skin rash
- Lactic acidosis (rare, serious)
- Vitamin B12 deficiency
- Weight gain (less common with metformin)
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis.
- Pregnancy - Generally not recommended during pregnancy; insulin is often preferred. Consult your doctor.
- Breastfeeding - Metformin passes into breast milk; gliclazide data is limited. Use with caution and medical advice.
- Liver - Use with caution in patients with liver impairment; may increase risk of lactic acidosis and hypoglycemia.
- Kidney - Contraindicated in severe renal impairment due to increased risk of lactic acidosis. Dose adjustment needed for moderate impairment.
- Lung - Use with caution in severe respiratory conditions that may predispose to hypoxia and lactic acidosis.
Disclaimer
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