About
GLYCIPHAGE SR 500MG TAB contains Metformin in a sustained-release (SR) formulation, an essential oral biguanide antihyperglycemic agent widely prescribed for the effective management of type 2 diabetes mellitus. The sustained-release characteristic of this formulation is designed to provide a slower, more gradual, and prolonged release of the active ingredient throughout the day. This controlled release mechanism often translates into significantly improved gastrointestinal tolerability, reducing common side effects such as nausea and diarrhea, and offers the added convenience of a once-daily dosing regimen, a notable advantage over immediate-release metformin. Metformin primarily exerts its therapeutic effects by decreasing glucose production in the liver, reducing the absorption of glucose from the intestines, and crucially, enhancing the body's sensitivity to insulin. This comprehensive action helps to lower blood sugar levels effectively without directly stimulating insulin secretion, thereby minimizing the inherent risk of hypoglycemia.
Uses
- Management of type 2 diabetes mellitus.
- Improvement of glycemic control with better tolerability.
- Reduction of postprandial and fasting blood glucose.
- Enhancement of insulin sensitivity.
Directions For Use
Take one tablet orally, usually once daily with the evening meal, or as directed by your physician. Swallow the tablet whole; do not crush, chew, or break.
Benefits
- Effective in lowering blood glucose levels.
- Improved gastrointestinal tolerability compared to immediate-release.
- Convenient once-daily dosing.
- Low risk of hypoglycemia when used alone.
- Does not typically cause weight gain.
- May offer cardiovascular benefits.
Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Vomiting
- Flatulence
- Loss of appetite
- Metallic taste in mouth
- Vitamin B12 deficiency (long-term use)
- Lactic acidosis (rare but serious)
- Headache
- Dizziness
- Fatigue
Safety Measures
- Alcohol - Alcohol can increase the risk of lactic acidosis, a rare but serious side effect of metformin. Avoid excessive alcohol consumption.
- Pregnancy - Consult a doctor. Metformin may be used in pregnancy for gestational diabetes or PCOS, but only under strict medical supervision.
- Breastfeeding - Metformin passes into breast milk in small amounts. Generally considered compatible with breastfeeding, but consult a doctor.
- Liver - Use with caution in patients with hepatic impairment, as it can increase the risk of lactic acidosis.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment is required for moderate impairment.
- Lung - No specific contraindications related to lung conditions, but caution is advised in conditions causing hypoxia, which can increase lactic acidosis risk.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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