About
Glyxambi is a combination medication containing empagliflozin and linagliptin, used to improve glycemic control in adults with type 2 diabetes mellitus. Empagliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption and increasing glucose excretion in the urine. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases incretin hormone levels, leading to enhanced glucose-dependent insulin secretion and reduced glucagon secretion. This dual mechanism of action helps to lower blood glucose levels effectively.
This medication is typically used as an adjunct to diet and exercise. It has been shown to reduce HbA1c levels and may also offer cardiovascular benefits, including a reduction in the risk of cardiovascular death in patients with established cardiovascular disease. It is important to note that Glyxambi is not indicated for type 1 diabetes or for the treatment of diabetic ketoacidosis. Regular monitoring of blood glucose and kidney function is recommended during treatment.
Uses
- To improve glycemic control in adults with type 2 diabetes mellitus.
- As an adjunct to diet and exercise.
- To reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.
- When both empagliflozin and linagliptin are appropriate for treatment.
Directions For Use
Take orally once daily in the morning, with or without food, as directed by your physician. Swallow the tablet whole.
Benefits
- Effectively lowers blood glucose levels.
- Combines two distinct mechanisms of action.
- May reduce the risk of cardiovascular death.
- Convenient once-daily dosing.
- Can lead to modest weight loss.
- Improves overall glycemic control.
Side Effects
- Urinary tract infections
- Genital yeast infections
- Increased urination
- Nausea
- Diarrhea
- Headache
- Joint pain
- Hypoglycemia (when used with insulin or sulfonylureas)
- Ketoacidosis (rare)
- Kidney problems
- Pancreatitis (rare)
- Allergic reactions
Safety Measures
- Alcohol - Limit alcohol intake as excessive alcohol can increase the risk of ketoacidosis.
- Pregnancy - Not recommended during pregnancy, especially in the second and third trimesters, due to potential fetal kidney effects.
- Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk.
- Liver - Use with caution in patients with liver impairment; monitor liver function.
- Kidney - Not recommended for severe kidney impairment (eGFR <30 mL/min/1.73 m²); dose adjustments for moderate impairment.
- Lung - Generally safe for use in patients with lung conditions; no specific contraindications.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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