ITRAGREAT 200

About

ITRAGREAT 200 contains Itraconazole, a broad-spectrum triazole antifungal agent. Itraconazole works by inhibiting the fungal cytochrome P450-dependent enzyme lanosterol 14α-demethylase, which is essential for the biosynthesis of ergosterol, a vital component of the fungal cell membrane. This inhibition leads to a disruption in fungal cell membrane integrity and function, ultimately resulting in the death of the fungal organism. ITRAGREAT 200 is effective against a wide range of fungal pathogens, including dermatophytes, yeasts, and various dimorphic fungi. It is commonly used for systemic fungal infections, including candidiasis, aspergillosis, histoplasmosis, and blastomycosis, as well as for superficial infections like onychomycosis, providing a potent solution for both localized and disseminated fungal diseases.

Uses

• Treatment of systemic fungal infections (e.g., aspergillosis, candidiasis).
• Management of onychomycosis (fungal nail infection).
• Eradication of histoplasmosis and blastomycosis.
• Treatment of oral and esophageal candidiasis.

Directions For Use

Take one capsule orally after a full meal, as directed by your physician. Swallow the capsule whole with water.

Benefits

• Broad-spectrum antifungal activity.
• Effective against systemic and superficial infections.
• High bioavailability when taken with food.
• Long half-life allows for less frequent dosing.
• Penetrates various tissues effectively.
• Reduces recurrence of fungal infections.

Side Effects

• Nausea.
• Vomiting.
• Diarrhea.
• Abdominal pain.
• Headache.
• Dizziness.
• Rash.
• Pruritus.
• Elevated liver enzymes.
• Congestive heart failure (rare).
• Peripheral neuropathy (rare).
• Hypokalemia.

Safety Measures

• Alcohol - Avoid alcohol consumption as it can increase the risk of liver damage and exacerbate side effects like nausea and dizziness.
• Pregnancy - Contraindicated in pregnancy due to potential teratogenic effects. Effective contraception is required during and after treatment.
• Breastfeeding - Itraconazole is excreted in breast milk. Avoid use during breastfeeding or consider temporary cessation of nursing.
• Liver - Contraindicated in patients with active liver disease or a history of liver failure. Monitor liver function tests regularly.
• Kidney - Use with caution in patients with renal impairment; dose adjustment may be necessary, and monitoring is recommended.
• Lung - Use with caution in patients with a history of congestive heart failure or other cardiac conditions, as it can exacerbate these.

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