JUSTOZA 10 10S

About

Dapagliflozin is an oral antidiabetic medication classified as a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine. This mechanism effectively lowers blood glucose levels independently of insulin secretion or sensitivity. Beyond its primary role in glycemic control for type 2 diabetes, dapagliflozin has demonstrated significant cardiovascular and renal benefits. It reduces the risk of cardiovascular death and hospitalization for heart failure in patients with type 2 diabetes and established cardiovascular disease or multiple risk factors. Furthermore, it slows the progression of chronic kidney disease in patients with or without type 2 diabetes. Its action also contributes to modest weight loss and blood pressure reduction.

Uses

• Management of type 2 diabetes mellitus.
• Reduction of cardiovascular risk in type 2 diabetes.
• Treatment of heart failure with reduced ejection fraction.
• Slowing the progression of chronic kidney disease.

Directions For Use

Take orally once daily in the morning, with or without food, as prescribed by your doctor.

Benefits

• Effectively lowers blood glucose and HbA1c.
• Promotes modest weight loss.
• Reduces blood pressure.
• Lowers risk of cardiovascular events and heart failure hospitalization.
• Slows the progression of kidney disease.
• Insulin-independent mechanism of action.

Side Effects

• Genital yeast infections
• Urinary tract infections
• Increased urination
• Thirst
• Dizziness
• Hypotension (low blood pressure)
• Ketoacidosis (rare but serious)
• Kidney problems (acute)
• Fournier's gangrene (very rare)
• Back pain
• Flu-like symptoms
• Nausea

Safety Measures

• Alcohol - May increase the risk of dehydration, low blood sugar, or, rarely, ketoacidosis. Limit alcohol intake.
• Pregnancy - Not recommended during pregnancy due to potential adverse effects on fetal kidney development.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it passes into breast milk.
• Liver - Use with caution in patients with severe hepatic impairment.
• Kidney - Contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73m²) or on dialysis.
• Lung - No specific contraindication, but monitor hydration status, especially in patients with respiratory conditions.

Disclaimer

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