LIZOFORCE D/SYP 30ML

About

LIZOFORCE D/SYP 30ML contains Linezolid, an oxazolidinone antibiotic, which is highly effective against Gram-positive bacteria, including multi-drug resistant strains such as Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococci (VRE). Linezolid exerts its antibacterial action by inhibiting bacterial protein synthesis at the ribosomal level, specifically by binding to the 23S ribosomal RNA of the 50S subunit, thereby preventing the formation of the initiation complex. This unique mechanism of action helps to overcome resistance mechanisms developed against other classes of antibiotics.

This dry syrup formulation is designed for oral administration, providing a convenient option for treating serious infections, particularly in pediatric patients or those who cannot tolerate intravenous therapy. It is well-absorbed from the gastrointestinal tract and widely distributed into various tissues and fluids. Due to its potent activity against resistant pathogens, Linezolid is often reserved for specific indications where other antibiotics may be ineffective. Careful monitoring for potential side effects, especially myelosuppression, is important during treatment.

Uses

• Treatment of Methicillin-resistant Staphylococcus aureus (MRSA) infections
• Management of Vancomycin-resistant Enterococci (VRE) infections
• Therapy for community-acquired pneumonia
• Effective against hospital-acquired pneumonia

Directions For Use

Administer orally as prescribed by your physician, usually twice daily. Reconstitute the dry syrup with sterile water as directed before use.

Benefits

• Effective against multi-drug resistant Gram-positive bacteria
• Good oral bioavailability
• Broad tissue distribution
• Suitable for severe infections
• Available in pediatric formulation
• Unique mechanism of action

Side Effects

• Nausea
• Diarrhea
• Headache
• Insomnia
• Dizziness
• Taste alteration (metallic taste)
• Myelosuppression (e.g., thrombocytopenia, anemia)
• Peripheral neuropathy
• Optic neuropathy
• Lactic acidosis
• Serotonin syndrome (with concomitant serotonergic drugs)
• Elevated liver enzymes

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of certain side effects like headache or dizziness.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks. Consult your doctor.
• Breastfeeding - Not recommended without medical advice; Linezolid may pass into breast milk. Consult your doctor.
• Liver - Use with caution in patients with liver impairment; no specific dose adjustment usually needed, but monitor.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be needed.
• Lung - Generally safe for lung infections, but monitor for potential respiratory adverse effects.

Disclaimer

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