Mamofen 20mg Tablet

About

Mamofen, chemically known as Tamoxifen, is a widely utilized selective estrogen receptor modulator (SERM) primarily indicated for the treatment and prevention of breast cancer. Its mechanism of action involves competitively binding to estrogen receptors found in breast cancer cells, effectively blocking the proliferative effects of estrogen on these cells and thereby inhibiting tumor growth. This targeted action makes it particularly efficacious in hormone receptor-positive breast cancers. Mamofen is a cornerstone in both adjuvant therapy, administered post-surgery to significantly reduce the risk of cancer recurrence, and in the management of metastatic breast cancer. Beyond its anti-estrogenic effects in breast tissue, it exhibits estrogenic properties in other tissues like bone and the uterus, which contribute to its diverse side effect profile. The long-term administration of Mamofen has demonstrably improved survival rates and quality of life for many eligible patients, solidifying its role as a vital endocrine therapy in oncology.

Uses

• Adjuvant treatment of hormone receptor-positive breast cancer.
• Treatment of metastatic hormone receptor-positive breast cancer.
• Reduction in incidence of invasive breast cancer in high-risk women.
• Treatment of ductal carcinoma in situ (DCIS) after surgery and radiation.

Directions For Use

Take orally once or twice daily with or without food, as prescribed by your oncologist.

Benefits

• Reduces breast cancer recurrence risk.
• Effective in metastatic hormone-positive breast cancer.
• Can prevent breast cancer in high-risk individuals.
• Improves overall survival rates.
• Oral administration for convenience.
• May have beneficial effects on bone density.

Side Effects

• Hot flashes
• Nausea
• Vaginal discharge or bleeding
• Fluid retention
• Fatigue
• Mood swings
• Endometrial cancer (rare but serious)
• Blood clots (DVT, PE)
• Cataracts
• Stroke (rare)
• Hair thinning
• Skin rash

Safety Measures

• Alcohol - Moderate alcohol consumption is generally considered safe, but excessive intake may increase liver strain.
• Pregnancy - Absolutely contraindicated; it can cause fetal harm. Effective contraception is essential during treatment.
• Breastfeeding - Contraindicated; the drug can pass into breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment; monitor liver function tests regularly.
• Kidney - Generally considered safe in patients with kidney conditions, but monitor for any unusual symptoms.
• Lung - No specific contraindications related to lung conditions, but monitor for symptoms of pulmonary embolism.

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