Tamtero 10mg Tablet

About

Tamtero 10mg Tablet is a selective estrogen receptor modulator (SERM) that functions as an anti-estrogen in breast tissue. It competitively binds to estrogen receptors, thereby inhibiting the growth-promoting effects of estrogen on estrogen receptor-positive (ER+) breast cancer cells. This action is crucial in preventing the recurrence of breast cancer and reducing the risk of developing new primary breast cancers in high-risk individuals. While acting as an anti-estrogen in the breast, it may exhibit estrogenic effects in other tissues, such as bone. This oral medication is a cornerstone in the long-term endocrine therapy for ER+ breast cancer.

Uses

• Reduction in incidence of invasive breast cancer in high-risk women
• Reduction in incidence of contralateral breast cancer
• Adjuvant treatment of ER+ breast cancer (in some protocols)
• Treatment of metastatic ER+ breast cancer (in some protocols)

Directions For Use

Taken orally, usually once or twice daily, with or without food, as prescribed by a doctor.

Benefits

• Reduces the risk of breast cancer development
• Effective in preventing breast cancer recurrence
• Improves long-term outcomes for ER+ breast cancer
• Generally well-tolerated in many patients
• Convenient oral administration for long-term use
• Established efficacy in endocrine therapy

Side Effects

• Hot flashes
• Vaginal discharge
• Nausea
• Fatigue
• Fluid retention
• Mood changes
• Endometrial changes (hyperplasia, polyps)
• Thromboembolic events (blood clots)
• Cataracts
• Vision changes
• Skin rash
• Headache

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake may increase the risk of liver side effects.
• Pregnancy - Contraindicated. Can cause fetal harm. Effective non-hormonal contraception is required during treatment and for two months after.
• Breastfeeding - Not recommended. Tamoxifen and its metabolites may be excreted in breast milk and could cause serious adverse effects in the infant.
• Liver - Use with caution in patients with pre-existing liver disease. Monitor liver function tests regularly, as tamoxifen is metabolized by the liver.
• Kidney - No specific dose adjustment required for renal impairment, but caution is advised in severe renal dysfunction.
• Lung - No specific lung-related safety concerns, but monitor for signs of pulmonary embolism (e.g., sudden shortness of breath, chest pain) due to increased risk of blood clots.

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