MESNA 100MG 2ML INJ. AMP.

About

Mesna is a crucial uroprotectant agent specifically designed to mitigate the severe bladder toxicity, known as hemorrhagic cystitis, induced by oxazaphosphorine chemotherapy drugs such as ifosfamide and cyclophosphamide. These chemotherapeutic agents produce a toxic metabolite, acrolein, which can cause significant irritation and damage to the bladder lining, leading to inflammation and bleeding. Mesna works by acting as a sulfhydryl donor in the urinary tract, where it binds to and detoxifies acrolein, forming a stable, non-toxic thioether compound. This targeted detoxification prevents acrolein from interacting with the bladder epithelium, thereby safeguarding the urinary system. Its co-administration is essential for patients undergoing high-dose oxazaphosphorine therapy, allowing for the effective delivery of chemotherapy while significantly reducing the risk of debilitating bladder complications and improving patient tolerance to treatment.

Uses

• Prevention of ifosfamide-induced hemorrhagic cystitis.
• Prevention of cyclophosphamide-induced hemorrhagic cystitis.
• Protection of the urinary tract during high-dose oxazaphosphorine therapy.
• Reduction of bladder toxicity from certain chemotherapy drugs.

Directions For Use

Administered intravenously, typically as a bolus injection or continuous infusion, concurrently with ifosfamide or cyclophosphamide. Dosage and timing are crucial and determined by the treating physician.

Benefits

• Significantly reduces risk of hemorrhagic cystitis.
• Allows for higher doses of chemotherapy to be administered.
• Protects bladder integrity during treatment.
• Minimizes discomfort and complications from bladder irritation.
• Improves patient tolerance to chemotherapy.
• Essential for safe administration of specific cytotoxic agents.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Headache
• Dizziness
• Fatigue
• Fever
• Flushing
• Rash
• Injection site reactions
• Hypersensitivity reactions

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but general caution is advised due to potential for increased gastrointestinal upset.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks, as animal studies show some fetal toxicity. Consult a physician.
• Breastfeeding - It is unknown if mesna is excreted in human milk; caution is advised, and breastfeeding should generally be avoided.
• Liver - No specific dose adjustment is typically required for liver impairment, but monitor patients closely.
• Kidney - No specific dose adjustment is typically required for kidney impairment, but monitor renal function.
• Lung - No specific precautions for lung conditions are generally noted with mesna use.

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