Nanoxel 30mg Injection

About

Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is an advanced formulation of the antineoplastic agent paclitaxel, belonging to the taxane class, primarily used in the treatment of various solid tumors. Its mechanism of action involves promoting the assembly of microtubules from tubulin dimers and stabilizing them by preventing depolymerization. This leads to the inhibition of normal dynamic reorganization of the microtubule network, which is essential for vital interphase and mitotic cellular functions. Consequently, it causes cell cycle arrest at the G2/M phase and ultimately induces apoptosis in rapidly dividing cancer cells. The albumin-bound formulation allows for higher intratumoral concentrations of paclitaxel, bypasses the need for solvent-based premedication, and potentially improves tolerability and efficacy compared to conventional paclitaxel formulations.

Uses

• Metastatic breast cancer
• Non-small cell lung cancer
• Pancreatic adenocarcinoma
• Advanced gastric cancer (off-label)

Directions For Use

Administered intravenously by a healthcare professional. Dosage and schedule are determined by the specific cancer type, patient's body surface area, and overall health.

Benefits

• Effective against various solid tumors.
• Reduced hypersensitivity reactions compared to solvent-based paclitaxel.
• Higher tumor accumulation of paclitaxel.
• No need for steroid premedication.
• Improved response rates in some cancers.
• Can be used in combination or as monotherapy.

Side Effects

• Peripheral neuropathy
• Myelosuppression (neutropenia)
• Fatigue
• Nausea
• Diarrhea
• Alopecia (hair loss)
• Arthralgia/myalgia (joint/muscle pain)
• Hypersensitivity reactions (less common)
• Edema
• Mucositis
• Infections
• Anemia

Safety Measures

• Alcohol - Avoid alcohol as it may exacerbate gastrointestinal side effects and potentially interact with metabolism.
• Pregnancy - Contraindicated in pregnancy due to significant risk of fetal harm; effective contraception is mandatory.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution and dose adjustment in patients with hepatic impairment; monitor liver function closely.
• Kidney - Use with caution in patients with renal impairment; no specific dose adjustment guidelines, but monitor.
• Lung - Rare reports of interstitial pneumonitis; monitor for new or worsening respiratory symptoms like cough or dyspnea.

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