Nuparp 300mg Tablet

About

Nuparp 300mg Tablet is an advanced oral medication classified as a poly (ADP-ribose) polymerase (PARP) inhibitor, representing a key development in targeted cancer therapy. It functions by selectively targeting and inhibiting PARP enzymes, which are essential for repairing single-strand DNA breaks and maintaining genomic integrity in cells. By blocking these enzymes, Nuparp prevents cancer cells, especially those with pre-existing defects in homologous recombination repair pathways, such as BRCA mutations, from effectively repairing their DNA damage. This leads to an overwhelming accumulation of DNA lesions, triggering a process of synthetic lethality that results in the programmed death of cancer cells. This precise mechanism makes Nuparp a valuable therapeutic option for specific cancer types, offering a targeted approach to disrupt tumor growth and progression.

Uses

• Maintenance therapy for recurrent ovarian, fallopian tube, or primary peritoneal cancer.
• Treatment of advanced BRCA-mutated breast cancer.
• Management of metastatic castration-resistant prostate cancer with HRR gene mutations.
• Treatment of germline BRCA-mutated metastatic pancreatic cancer.

Directions For Use

Take Nuparp 300mg Tablet orally once daily, with or without food, as prescribed by your healthcare provider. Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Targets DNA repair pathways in susceptible cancer cells.
• Effective in patients with BRCA mutations.
• Offers a maintenance strategy to prolong remission.
• Improves disease-free survival in specific indications.
• Convenient oral administration.
• Part of personalized cancer treatment.

Side Effects

• Thrombocytopenia (low platelet count)
• Anemia (low red blood cell count)
• Neutropenia (low white blood cell count)
• Nausea
• Fatigue
• Constipation
• Vomiting
• Abdominal pain
• Headache
• Insomnia
• Hypertension
• Myelodysplastic Syndrome/Acute Myeloid Leukemia (rare)

Safety Measures

• Alcohol - It is advisable to limit or avoid alcohol intake during treatment, as it may worsen certain side effects or interact with the medication.
• Pregnancy - Nuparp is embryofetal toxic. Women of reproductive potential must use highly effective contraception during treatment and for 6 months after the last dose.
• Breastfeeding - Due to the potential for serious adverse reactions in breastfed infants, breastfeeding is not recommended during Nuparp treatment and for 1 month after the last dose.
• Liver - Exercise caution in patients with pre-existing liver conditions. Dose adjustments may be necessary, and liver function should be monitored regularly.
• Kidney - Patients with moderate or severe renal impairment may require dose modifications. Renal function should be assessed before and during therapy.
• Lung - Interstitial lung disease/pneumonitis is a rare but serious side effect. Patients should report any new or worsening respiratory symptoms promptly.

Disclaimer

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