About
This medication represents a potent triple-combination therapy specifically formulated for the robust management of essential hypertension, especially in patients whose blood pressure is not adequately controlled by dual therapy. It comprises Olmesartan, an angiotensin II receptor blocker (ARB); Amlodipine, a dihydropyridine calcium channel blocker (CCB); and Hydrochlorothiazide, a thiazide diuretic. Olmesartan works by blocking the AT1 receptor, thereby inhibiting the vasoconstrictive and aldosterone-secreting actions of angiotensin II, leading to vasodilation. Amlodipine further contributes to blood pressure reduction by relaxing vascular smooth muscle, which decreases peripheral vascular resistance. Hydrochlorothiazide complements these actions by increasing the renal excretion of sodium and water, consequently reducing blood volume. This synergistic approach targets multiple distinct pathophysiological pathways involved in blood pressure regulation, providing comprehensive and sustained antihypertensive efficacy. The combination aims to achieve optimal blood pressure control, thereby reducing the overall risk of cardiovascular events.
Uses
- Treatment of essential hypertension.
- Management of severe or resistant hypertension.
- Reduction of cardiovascular events in high-risk patients.
- When blood pressure is not controlled by monotherapy or dual therapy.
Directions For Use
Take one tablet orally once daily, preferably at the same time each day, with or without food.
Benefits
- Potent and comprehensive blood pressure control.
- Targets multiple mechanisms of hypertension.
- Reduces the risk of major cardiovascular events.
- Convenient once-daily dosing for improved adherence.
- Effective for patients with resistant hypertension.
- May reduce peripheral edema associated with Amlodipine.
Side Effects
- Dizziness
- Headache
- Peripheral edema
- Fatigue
- Nausea
- Hypotension
- Hyperkalemia (Olmesartan)
- Hypokalemia (Hydrochlorothiazide)
- Muscle cramps
- Increased urination
- Cough (less common than ACEIs)
- Gout exacerbation (Hydrochlorothiazide)
Safety Measures
- Alcohol - Avoid alcohol as it can exacerbate dizziness and hypotensive effects, especially with the diuretic component.
- Pregnancy - Contraindicated during pregnancy due to the risk of fetal harm from Olmesartan and potential effects from Hydrochlorothiazide.
- Breastfeeding - Not recommended; components may pass into breast milk and could harm the infant.
- Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary, especially with Amlodipine.
- Kidney - Contraindicated in anuria; use with caution and monitor function in severe renal impairment due to all components.
- Lung - Generally safe; however, monitor for any unusual respiratory symptoms, especially in patients with pre-existing conditions.
Disclaimer
MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.
Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
| Shipping Cost |
|
| Shop Location | Assam, India |
No comments found for this product. Be the first to comment!