OLKEM 20 AM 15 S

About

OLKEM 20 AM is a sophisticated combination medication that integrates Olmesartan, an angiotensin II receptor blocker (ARB), with Amlodipine, a dihydropyridine calcium channel blocker. This synergistic formulation is specifically engineered to provide enhanced and more comprehensive blood pressure control than either component used individually. Olmesartan works by relaxing blood vessels through the blockade of angiotensin II, while Amlodipine further dilates both arterial and venous smooth muscle, reducing peripheral vascular resistance. The combined action results in a significant and sustained reduction in high blood pressure, effectively lowering the risk of major cardiovascular events such as heart attacks, strokes, and kidney damage in patients with essential hypertension who require more aggressive blood pressure management.

Uses

• Treatment of essential hypertension.
• When monotherapy with either Olmesartan or Amlodipine is insufficient.
• To achieve optimal blood pressure control.
• Reduction of overall cardiovascular risk in hypertensive patients.

Directions For Use

Take one tablet orally once daily, with or without food, as prescribed by your doctor.

Benefits

• Provides superior blood pressure reduction compared to monotherapy.
• Offers comprehensive 24-hour blood pressure control.
• Reduces the risk of major cardiovascular events.
• Combines two distinct mechanisms for enhanced efficacy.
• May improve patient adherence due to single pill regimen.
• Effective in a broad range of hypertensive patients.

Side Effects

• Dizziness
• Headache
• Peripheral edema (swelling of ankles/feet)
• Fatigue
• Nausea
• Flushing
• Palpitations
• Abdominal pain
• Hyperkalemia (less common than with ARB alone)
• Hypotension
• Gingival hyperplasia (rare with amlodipine)
• Upper respiratory tract infection

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can intensify the blood pressure-lowering effect and increase dizziness.
• Pregnancy - Contraindicated in the second and third trimesters due to risk of fetal harm from Olmesartan. Consult a doctor immediately if pregnant.
• Breastfeeding - Not recommended; both components may pass into breast milk and pose risks to the infant. Seek medical advice before use.
• Liver - Use with caution in patients with severe liver impairment; dose adjustment may be necessary for both components.
• Kidney - Monitor kidney function closely, especially in patients with renal artery stenosis or severe renal impairment.
• Lung - Generally safe for use in patients with lung conditions, as neither component typically affects respiratory function.

Disclaimer

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