Oncothal 100mg Capsule

About

Oncothal 100mg Capsule, containing thalidomide, is an immunomodulatory drug with a complex mechanism of action, including anti-inflammatory, anti-angiogenic, and immunomodulatory properties. Initially infamous for its teratogenic effects, it has been repurposed and is now a crucial medication in specific clinical settings, primarily for the treatment of multiple myeloma. Its therapeutic effects in multiple myeloma are thought to involve inhibition of angiogenesis, modulation of cytokine production (e.g., TNF-alpha), and direct anti-tumor activity by inducing apoptosis in myeloma cells.

Beyond oncology, thalidomide is also approved for the treatment of moderate to severe erythema nodosum leprosum (ENL), a painful inflammatory complication of leprosy. Due to its severe teratogenicity, Oncothal is subject to strict risk management programs to prevent exposure during pregnancy. Patients must adhere to stringent prescribing and dispensing protocols, including mandatory contraception.

Uses

• Treatment of multiple myeloma.
• Management of erythema nodosum leprosum (ENL).
• Certain dermatological conditions (off-label).
• Investigational use in other cancers.

Directions For Use

Take Oncothal 100mg Capsule orally, usually at bedtime, with water. Adhere strictly to the prescribed dosage and the mandatory risk management program, including contraception.

Benefits

• Effective in treating multiple myeloma.
• Reduces inflammation in ENL.
• Exhibits anti-angiogenic properties.
• Modulates immune responses.
• Improves quality of life in specific conditions.
• Well-studied and established in its indications.

Side Effects

• Drowsiness and sedation
• Peripheral neuropathy
• Constipation
• Skin rash
• Fatigue
• Dizziness
• Deep vein thrombosis (DVT)
• Pulmonary embolism (PE)
• Bradycardia
• Tremor
• Teratogenicity (severe birth defects)
• Neutropenia and thrombocytopenia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to increased risk of drowsiness, dizziness, and sedation, which can be exacerbated by Oncothal.
• Pregnancy - Oncothal is ABSOLUTELY CONTRAINDICATED during pregnancy due to severe teratogenicity. Women of childbearing potential must use two reliable forms of contraception.
• Breastfeeding - Breastfeeding is not recommended during Oncothal treatment, as the drug may pass into breast milk and pose a significant risk to the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary, and liver function should be closely monitored throughout therapy.
• Kidney - Use with caution in patients with kidney impairment; dose adjustments may be necessary, and renal function should be closely monitored.
• Lung - Increased risk of thromboembolic events, including pulmonary embolism (PE). Monitor patients for symptoms such as shortness of breath, chest pain, or swelling in the legs.

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