About
Olanzapine, the active ingredient in ORESTA 10MG TAB, is an atypical antipsychotic medication primarily used in the management of various psychiatric conditions. It exerts its therapeutic effects by modulating the activity of several neurotransmitters in the brain, including dopamine and serotonin. Specifically, it acts as an antagonist at multiple dopamine D1, D2, D3, D4, and D5 receptors, as well as serotonin 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, and 5-HT6 receptors. This broad receptor binding profile contributes to its efficacy in alleviating both positive and negative symptoms of psychosis, as well as mood stabilization. Its mechanism also involves antagonism at muscarinic M1-M5 receptors, alpha1-adrenergic receptors, and histamine H1 receptors, which can contribute to some of its side effects. Olanzapine is known for its effectiveness in reducing psychotic symptoms and improving mood, making it a valuable tool in mental health treatment.
Uses
- Treatment of schizophrenia.
- Management of bipolar I disorder (manic or mixed episodes).
- Maintenance treatment of bipolar I disorder.
- Treatment of agitation associated with schizophrenia or bipolar mania.
Directions For Use
Take this medication orally, usually once daily, with or without food, as prescribed by your doctor. Do not crush or chew the tablet.
Benefits
- Effective in reducing psychotic symptoms.
- Helps stabilize mood in bipolar disorder.
- Can alleviate agitation.
- Available in various formulations for flexibility.
- Improves overall mental well-being.
- Contributes to long-term disease management.
Side Effects
- Drowsiness
- Weight gain
- Dry mouth
- Constipation
- Dizziness
- Increased appetite
- Orthostatic hypotension
- Restlessness
- Tremor
- Increased cholesterol levels
- Increased blood sugar levels
- Akathisia
Safety Measures
- Alcohol - Avoid alcohol consumption as it can intensify central nervous system depressant effects, leading to increased drowsiness and dizziness.
- Pregnancy - Use with caution; potential risks and benefits should be discussed with a healthcare provider. Neonates exposed during the third trimester may be at risk for withdrawal symptoms.
- Breastfeeding - Not recommended as olanzapine is excreted into breast milk and may cause adverse effects in the infant. Consult a doctor.
- Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Regular monitoring of liver function is advised.
- Kidney - Generally considered safe in renal impairment, but caution is advised. No specific dose adjustment is usually required, but monitor for adverse effects.
- Lung - No specific contraindications related to lung conditions, but monitor for respiratory depression if used with other CNS depressants.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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