PALNOX 5ML INJ VIAL

About

Palonosetron is a highly selective 5-HT3 receptor antagonist distinguished by its prolonged duration of action and high binding affinity. Its therapeutic effect stems from blocking serotonin, a key neurotransmitter involved in inducing nausea and vomiting, from binding to 5-HT3 receptors. These receptors are strategically located in the chemoreceptor trigger zone in the brainstem and on vagal nerve terminals within the gastrointestinal tract. By inhibiting these receptors, palonosetron effectively prevents both acute and, notably, delayed chemotherapy-induced nausea and vomiting (CINV), which is often a significant challenge with moderately and highly emetogenic chemotherapy regimens. Furthermore, it is also highly effective in preventing postoperative nausea and vomiting (PONV). Its extended half-life contributes significantly to its superior efficacy in managing delayed emesis, providing sustained relief and improving patient comfort during and after medical procedures.

Uses

• Prevention of acute CINV
• Prevention of delayed CINV
• Prevention of PONV
• Highly emetogenic chemotherapy

Directions For Use

Administer intravenously as a single dose prior to chemotherapy or surgery, as directed by a healthcare professional.

Benefits

• Effective against acute CINV
• Effective against delayed CINV
• Prevents PONV
• Long duration of action
• Highly selective 5-HT3 antagonist
• Improves patient comfort during treatment

Side Effects

• Headache
• Constipation
• Diarrhea
• Dizziness
• Fatigue
• Bradycardia
• Hypotension
• Injection site reactions
• QT prolongation (rare)
• Abdominal pain
• Insomnia
• Rash

Safety Measures

• Alcohol - No specific contraindication, but alcohol can exacerbate nausea.
• Pregnancy - Use only if clearly needed; consult a physician.
• Breastfeeding - Exercise caution; consider discontinuing breastfeeding or the drug.
• Liver - No dose adjustment generally needed for liver impairment.
• Kidney - No dose adjustment generally needed for kidney impairment.
• Lung - No specific precautions for lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.