PALONOLIVE 0.25 MG INJ. VIAL.

About

Palonolive (palonosetron) is a highly selective 5-HT3 receptor antagonist indicated for the prevention of chemotherapy-induced nausea and vomiting (CINV), both acute and delayed, and for the prevention of postoperative nausea and vomiting (PONV). It works by blocking serotonin, a natural substance in the body that can cause nausea and vomiting, from binding to 5-HT3 receptors in the gastrointestinal tract and the chemoreceptor trigger zone in the brain.

Palonosetron has a prolonged duration of action and a high receptor binding affinity, making it particularly effective in preventing delayed CINV, which is often a significant challenge for patients undergoing chemotherapy, thereby improving patient comfort and quality of life.

Uses

• Prevention of acute chemotherapy-induced nausea and vomiting.
• Prevention of delayed chemotherapy-induced nausea and vomiting.
• Prevention of postoperative nausea and vomiting.
• Used in adults and pediatric patients.

Directions For Use

Administer intravenously as a single dose prior to chemotherapy or surgery, as directed by a healthcare professional.

Benefits

• Highly effective in preventing CINV.
• Prevents both acute and delayed CINV.
• Effective for postoperative nausea and vomiting.
• Long duration of action.
• High receptor binding affinity.
• Improves patient comfort during treatment.

Side Effects

• Headache
• Constipation
• Diarrhea
• Dizziness
• Fatigue
• Bradycardia
• Hypotension
• Injection site pain
• Abdominal pain
• Insomnia
• Rash
• Anxiety

Safety Measures

• Alcohol - Generally safe, but alcohol can exacerbate nausea; moderate intake is advisable.
• Pregnancy - Use only if clearly needed; consult a physician to weigh potential benefits against risks to the fetus.
• Breastfeeding - Use with caution; it is unknown if palonosetron is excreted in human milk.
• Liver - No dose adjustment is required for patients with hepatic impairment.
• Kidney - No dose adjustment is required for patients with renal impairment.
• Lung - No specific contraindications; generally considered safe for individuals with lung conditions.

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