Pazeqol 400mg Tablet

About

Pazopanib is a sophisticated, multi-targeted receptor tyrosine kinase inhibitor designed to combat various forms of cancer. Its mechanism of action involves selectively inhibiting the activity of several crucial receptors, including vascular endothelial growth factor receptor (VEGFR)-1, -2, and -3, platelet-derived growth factor receptor (PDGFR)-α and -β, and c-Kit. By blocking these key signaling pathways, pazopanib effectively disrupts the processes of angiogenesis (the formation of new blood vessels that feed tumors), tumor cell proliferation, and survival. This targeted approach makes it particularly effective in the treatment of advanced renal cell carcinoma (RCC) and advanced soft tissue sarcoma (STS) in patients who have previously undergone chemotherapy. Its ability to interfere with multiple growth factor pathways provides a comprehensive strategy to inhibit tumor progression and metastasis, offering a significant therapeutic option for these challenging cancers.

Uses

• Advanced renal cell carcinoma
• Advanced soft tissue sarcoma
• Certain other solid tumors
• Metastatic disease management

Directions For Use

Take orally, usually once daily, at least one hour before or two hours after a meal.

Benefits

• Targeted therapy for specific cancers
• Slows tumor growth and progression
• Improves progression-free survival
• Oral administration for convenience
• Effective in advanced RCC and STS
• Reduces tumor vascularization

Side Effects

• Hypertension
• Fatigue
• Nausea
• Diarrhea
• Hair color changes
• Elevated liver enzymes
• Proteinuria
• Headache
• Vomiting
• Anorexia
• Hand-foot syndrome
• Rash

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to the potential for increased liver toxicity and adverse effects while on this medication.
• Pregnancy - This medication is contraindicated during pregnancy as it can cause severe fetal harm. Women of childbearing potential must use effective contraception.
• Breastfeeding - Breastfeeding is not recommended as it is unknown if the drug is excreted in human milk, posing a potential risk of serious adverse reactions in the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Close monitoring of liver function tests is essential.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustments may be considered. No specific adjustments for mild to moderate impairment.
• Lung - Monitor for signs of interstitial lung disease or pneumonitis. Discontinue treatment if these conditions are suspected or confirmed.

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