Pazolong 200mg Tablet

About

Pazolong 200mg Tablet contains pazopanib, an oral multi-targeted receptor tyrosine kinase inhibitor. This medication functions by selectively inhibiting several key enzymes, including vascular endothelial growth factor receptors (VEGFR-1, -2, -3), platelet-derived growth factor receptors (PDGFR-α/β), and c-Kit. These tyrosine kinases play critical roles in tumor angiogenesis (the formation of new blood vessels that feed tumors) and the proliferation of cancer cells. By blocking these specific pathways, pazopanib effectively disrupts the growth and spread of malignant cells.

It is primarily indicated for the treatment of certain advanced cancers, where it helps to slow disease progression and improve patient outcomes by targeting the underlying molecular mechanisms driving tumor development. Its comprehensive inhibitory action against multiple growth factor receptors makes it a valuable therapeutic agent in oncology, particularly for tumors that exhibit dependence on these signaling pathways for their survival and metastatic potential.

Uses

• Treatment of advanced renal cell carcinoma (RCC).
• Management of advanced soft tissue sarcoma (STS).
• Inhibition of tumor angiogenesis.
• Slowing the progression of certain metastatic cancers.

Directions For Use

Take this medicine exactly as prescribed by your doctor, usually once daily on an empty stomach, at least one hour before or two hours after a meal.

Benefits

• Targets multiple pathways involved in cancer growth.
• Effective in treating advanced kidney cancer.
• Provides a treatment option for certain soft tissue sarcomas.
• Helps to inhibit the formation of new blood vessels to tumors.
• Can slow the progression of metastatic disease.
• Administered orally, offering convenience.

Side Effects

• High blood pressure (hypertension)
• Fatigue and weakness
• Diarrhea
• Nausea and vomiting
• Loss of appetite (anorexia)
• Changes in hair color
• Elevated liver enzymes
• Protein in urine (proteinuria)
• Hand-foot syndrome
• Headache
• Taste disturbance (dysgeusia)
• Weight loss

Safety Measures

• Alcohol - Limit or avoid alcohol consumption as it may exacerbate liver-related side effects associated with this medication.
• Pregnancy - Pazolong 200mg Tablet is contraindicated during pregnancy due to potential harm to the fetus. Effective contraception is required for women of childbearing potential.
• Breastfeeding - Breastfeeding is not recommended during treatment and for at least 2 weeks after the last dose, as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with pre-existing liver conditions. Regular monitoring of liver function tests is essential, and dose adjustments may be necessary.
• Kidney - Exercise caution in patients with kidney impairment. No specific dose adjustment is typically needed for mild to moderate impairment, but severe impairment requires careful consideration.
• Lung - Monitor for new or worsening respiratory symptoms, as there is a risk of interstitial lung disease or pneumonitis. Seek immediate medical attention if symptoms occur.

Disclaimer

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