About
PEMCURE (Pemetrexed) is an antineoplastic agent belonging to the class of antifolates. It works by inhibiting several folate-dependent enzymes involved in purine and pyrimidine synthesis, which are essential for cell replication. This disruption leads to DNA synthesis inhibition and ultimately cell death, particularly in rapidly dividing cancer cells. It is administered intravenously and is primarily used in the treatment of certain types of cancer, either alone or in combination with other chemotherapeutic agents.
Pemetrexed's mechanism of action targets multiple pathways, making it effective against various solid tumors. Its clinical efficacy has been demonstrated in improving progression-free survival and overall survival in specific patient populations. Patients typically receive premedication with corticosteroids, folic acid, and vitamin B12 to mitigate certain side effects and enhance tolerability.
Uses
- Non-small cell lung cancer (NSCLC)
- Malignant pleural mesothelioma
- Advanced or metastatic solid tumors
- Maintenance therapy for NSCLC
Directions For Use
Administered intravenously by a healthcare professional. Dosage and frequency are determined by your doctor based on your condition and body surface area.
Benefits
- Effective against specific types of lung cancer
- Can improve survival rates in mesothelioma patients
- May be used as first-line or maintenance therapy
- Often well-tolerated with appropriate premedication
- Part of established chemotherapy regimens
- Targets multiple pathways for anti-tumor activity
Side Effects
- Nausea and vomiting
- Fatigue and weakness
- Diarrhea or constipation
- Loss of appetite
- Hair thinning
- Rash or skin reactions
- Mouth sores (stomatitis)
- Low blood cell counts (anemia, neutropenia, thrombocytopenia)
- Fever
- Peripheral neuropathy
- Kidney dysfunction
- Liver enzyme elevations
Safety Measures
- Alcohol - Avoid alcohol during treatment as it may exacerbate liver toxicity and other side effects.
- Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Effective contraception is required for both male and female patients during and after treatment.
- Breastfeeding - Breastfeeding is not recommended during treatment and for a period after the last dose due to potential harm to the infant.
- Liver - Use with caution in patients with pre-existing liver impairment; dose adjustments may be necessary. Regular monitoring of liver function is essential.
- Kidney - Dose adjustments are required for patients with moderate to severe renal impairment. Close monitoring of kidney function is crucial.
- Lung - Use with caution in patients with pre-existing lung conditions. Monitor for new or worsening pulmonary symptoms, such as dyspnea or cough.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
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