Pemgem 500mg Injection

About

Pemgem 500mg Injection contains Gemcitabine, a nucleoside analog antimetabolite that acts as a potent chemotherapeutic agent. It works by interfering with DNA synthesis and repair, leading to cell death. Once inside the cell, gemcitabine is phosphorylated to its active diphosphate and triphosphate forms. Gemcitabine diphosphate inhibits ribonucleotide reductase, an enzyme crucial for DNA synthesis, while gemcitabine triphosphate is incorporated into DNA strands, causing chain termination and inhibiting DNA polymerase. This dual mechanism effectively disrupts the proliferation of rapidly dividing cancer cells. It is widely used in the treatment of various solid tumors, including pancreatic, breast, non-small cell lung, and ovarian cancers, either alone or in combination with other agents.

Uses

• Treatment of pancreatic cancer
• Management of non-small cell lung cancer (NSCLC)
• Therapy for advanced breast cancer
• Treatment of ovarian cancer

Directions For Use

Administered intravenously by a healthcare professional. Dosage and administration schedule are tailored to the specific cancer type and patient's condition.

Benefits

• Broad-spectrum activity against various solid tumors.
• Can improve survival rates in pancreatic cancer.
• Effective in combination with other chemotherapies.
• Helps to reduce tumor burden.
• Offers a systemic treatment option.
• Well-established efficacy in oncology.

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Fatigue and asthenia
• Fever
• Rash
• Peripheral edema
• Flu-like symptoms
• Hair loss (alopecia)
• Diarrhea or constipation
• Elevated liver enzymes
• Proteinuria
• Dyspnea

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to significant teratogenic potential. Women of childbearing potential must use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with pre-existing liver impairment; dose adjustments may be necessary.
• Kidney - Requires careful monitoring and dose adjustment in patients with renal dysfunction.
• Lung - Rarely, severe pulmonary toxicity, including interstitial pneumonitis, can occur; monitor for respiratory symptoms.

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