Pemnat 500mg Injection

About

Pemnat 500mg Injection contains Pemetrexed, an antifolate antineoplastic agent that functions by disrupting critical metabolic pathways essential for cell replication. It specifically inhibits several enzymes involved in the synthesis of purines and pyrimidines, which are fundamental building blocks of DNA and RNA. By interfering with these processes, Pemetrexed effectively halts DNA synthesis and repair, as well as protein synthesis, leading to cell cycle arrest and programmed cell death (apoptosis) in rapidly dividing cancer cells. This targeted mechanism makes it a valuable treatment option for various solid tumors. It is primarily indicated for the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma, offering a systemic approach to manage these aggressive malignancies. Its broad inhibitory action on folate-dependent enzymes contributes to its efficacy in oncology.

Uses

• Treatment of non-small cell lung cancer (NSCLC)
• Management of malignant pleural mesothelioma
• Used in combination or as monotherapy
• Targets rapidly dividing cancer cells

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and treatment schedule are individualized based on patient's condition and response.

Benefits

• Effective against specific lung cancers.
• Improves survival in mesothelioma patients.
• Can be used as first-line or maintenance therapy.
• Targets multiple cancer cell pathways.
• Helps to reduce tumor growth.
• Offers a systemic treatment option.

Side Effects

• Nausea and vomiting
• Fatigue and weakness
• Myelosuppression (low blood counts)
• Anemia
• Thrombocytopenia
• Neutropenia
• Mucositis/stomatitis
• Diarrhea
• Skin rash
• Hair loss (alopecia)
• Peripheral neuropathy
• Kidney dysfunction

Safety Measures

• Alcohol - Avoid alcohol consumption during treatment as it may worsen side effects like liver toxicity or gastrointestinal upset.
• Pregnancy - Contraindicated in pregnancy due to significant risk of fetal harm. Use effective contraception during and for a period after treatment.
• Breastfeeding - Not recommended during breastfeeding as the drug may be excreted in breast milk and pose risks to the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary based on liver function tests.
• Kidney - Requires careful monitoring and dose modification in patients with renal dysfunction due to its primary renal excretion.
• Lung - Rarely, interstitial lung disease can occur; monitor for new or worsening respiratory symptoms like cough or dyspnea.

Disclaimer

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