PEMETERO 500 MG INJ VIAL

About

PEMETERO 500 MG INJ VIAL, containing Pemetrexed, is a multitargeted antifolate antineoplastic agent used in the treatment of various cancers. It exerts its cytotoxic effects by disrupting several folate-dependent metabolic pathways essential for cell replication. Specifically, Pemetrexed inhibits key enzymes such as thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), which are involved in the biosynthesis of purine and pyrimidine nucleotides. This inhibition leads to the depletion of nucleotide precursors, thereby impairing DNA synthesis and repair, and ultimately inducing cell death in rapidly dividing cancer cells.

This medication is primarily indicated for the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma. To mitigate potential toxicities, particularly myelosuppression and skin reactions, patients are typically pre-medicated with folic acid and vitamin B12 supplements, and corticosteroids. Its efficacy, combined with a manageable side effect profile when appropriate supportive care is provided, makes it a valuable component in both first-line and maintenance therapy regimens for these challenging malignancies.

Uses

• Treatment of non-small cell lung cancer (NSCLC)
• Management of malignant pleural mesothelioma
• Used as monotherapy or in combination regimens
• Maintenance therapy for advanced NSCLC

Directions For Use

Administer intravenously over 10 minutes, as directed by an oncologist. Pre-medication with folic acid, vitamin B12, and a corticosteroid is typically required.

Benefits

• Effective against specific types of lung cancer and mesothelioma
• Improves survival rates in eligible patients
• Can be used in various stages of treatment
• Manageable side effect profile with pre-medication
• Targeted mechanism of action on cancer cell metabolism
• Contributes to extended disease control

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Fatigue
• Nausea
• Vomiting
• Stomatitis
• Diarrhea
• Skin rash
• Alopecia (hair loss)
• Kidney dysfunction
• Elevated liver enzymes
• Peripheral neuropathy
• Febrile neutropenia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to the potential for increased liver toxicity and gastrointestinal irritation, which can exacerbate side effects.
• Pregnancy - Contraindicated during pregnancy due to its teratogenic potential. Women of childbearing potential must use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it is excreted in human milk and could cause serious adverse reactions in the infant.
• Liver - Use with caution in patients with hepatic impairment. Monitor liver function closely, and dose adjustments may be necessary.
• Kidney - Dose adjustment is required in patients with moderate to severe renal impairment. It is contraindicated in severe renal impairment.
• Lung - Used for lung cancer treatment. Monitor for pulmonary toxicity, though rare, and manage any respiratory symptoms promptly.

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