PREGANAV SR NT

About

PREGANAV SR NT combines Pregabalin, an alpha-2-delta ligand that modulates voltage-gated calcium channels to reduce the release of excitatory neurotransmitters, with Nortriptyline, a tricyclic antidepressant known for its significant analgesic properties. Nortriptyline enhances the effects of norepinephrine and serotonin in the brain's pain modulation pathways. This synergistic combination is specifically formulated as a sustained-release (SR) preparation to provide comprehensive and prolonged relief for chronic neuropathic pain. Conditions such as diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia often benefit from this dual-action approach. The sustained-release mechanism ensures stable drug levels in the body, leading to consistent pain control throughout the day or night, improved sleep quality, and a reduction in the frequency of dosing, thereby enhancing patient convenience and compliance in long-term pain management.

Uses

• Neuropathic pain
• Fibromyalgia
• Post-herpetic neuralgia
• Diabetic neuropathy

Directions For Use

Take as prescribed by your doctor, usually once daily, preferably at bedtime.

Benefits

• Comprehensive nerve pain relief
• Sustained action for consistent control
• Improves sleep quality
• Reduces anxiety
• Effective for chronic conditions
• Dual mechanism of action

Side Effects

• Dizziness
• Drowsiness
• Dry mouth
• Constipation
• Weight gain
• Blurred vision
• Peripheral edema
• Urinary retention
• Confusion
• Orthostatic hypotension
• Fatigue
• Difficulty concentrating

Safety Measures

• Alcohol - Avoid or limit alcohol due to increased CNS depression, drowsiness, and dizziness.
• Pregnancy - Consult doctor; generally not recommended unless benefits outweigh risks.
• Breastfeeding - Consult doctor; components may pass into breast milk.
• Liver - Use with caution; dose adjustment may be needed for nortriptyline in severe impairment.
• Kidney - Dose adjustment required, especially for pregabalin component.
• Lung - Generally safe, but caution in patients with respiratory depression history due to CNS effects.

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