About

RANOGARD 500, containing ranolazine, is an anti-anginal medication specifically used to treat chronic stable angina (chest pain). Its unique mechanism of action involves selectively inhibiting the late sodium current in heart muscle cells. This inhibition helps to reduce intracellular calcium overload, which in turn improves myocardial relaxation and reduces myocardial oxygen demand without significantly affecting heart rate or blood pressure, thereby alleviating angina symptoms and improving cardiac function.

Ranolazine is often prescribed as an add-on therapy for patients whose angina is not adequately controlled by other anti-anginal medications, such as beta-blockers or calcium channel blockers, or for those who cannot tolerate these conventional treatments. It helps to improve exercise tolerance and reduce the frequency of angina episodes, significantly enhancing the quality of life for individuals suffering from chronic stable angina. Regular monitoring for potential QT prolongation is important, especially in patients with pre-existing cardiac conditions or those on other QT-prolonging drugs.

Uses

Treatment of chronic stable angina.
Adjunctive therapy for patients not adequately controlled by other anti-anginal drugs.
Improvement of exercise tolerance in angina patients.
Reduction in frequency of angina episodes.

Directions For Use

Take this medication orally, usually twice daily, with or without food, as directed by your doctor. Swallow the tablet whole; do not crush or chew.

Benefits

Effectively reduces the frequency and severity of angina attacks.
Improves exercise capacity in patients with chronic stable angina.
Does not significantly affect heart rate or blood pressure.
Can be used in combination with other anti-anginal therapies.
Offers a unique mechanism of action for angina management.
Enhances overall quality of life for angina sufferers.

Side Effects

Dizziness, lightheadedness
Nausea, constipation
Headache
Weakness, fatigue
Palpitations
Shortness of breath
Peripheral edema
QT prolongation (rare but serious)
Abdominal pain
Vomiting
Dry mouth
Syncope (fainting)

Safety Measures

Alcohol - No specific contraindication, but excessive alcohol can exacerbate dizziness or lightheadedness, which are common side effects of ranolazine.
Pregnancy - Limited data available. Use only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
Breastfeeding - It is unknown if ranolazine is excreted in human milk. Due to potential for serious adverse reactions in the infant, a decision should be made whether to discontinue nursing or the drug.
Liver - Contraindicated in patients with severe hepatic impairment. Use with caution and dose adjustment in moderate hepatic impairment.
Kidney - Use with caution in patients with moderate to severe renal impairment (CrCl < 60 mL/min) due to increased ranolazine exposure. Not recommended for CrCl < 30 mL/min.
Lung - No specific contraindications or significant concerns related to lung conditions are typically noted for ranolazine.

Disclaimer

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