RYZODEG PENFILL 3 ML

About

Ryzodeg Penfill 3ml is a unique co-formulation of insulin degludec (a long-acting basal insulin) and insulin aspart (a rapid-acting mealtime insulin). This innovative combination provides comprehensive glucose control by addressing both basal insulin needs for sustained blood sugar regulation and bolus insulin requirements for post-meal glucose spikes, all within a single injection. It is indicated for the treatment of diabetes mellitus in adults, adolescents, and children aged 1 year and above. Insulin degludec forms soluble multi-hexamers upon subcutaneous injection, creating a stable depot that ensures slow and continuous absorption, providing a flat and stable glucose-lowering effect for over 42 hours. Insulin aspart, conversely, acts quickly to manage glucose excursions after meals.

The dual action of Ryzodeg offers significant flexibility in dosing, typically administered once or twice daily with the main meal(s). This simplifies the insulin regimen for patients, potentially enhancing adherence and overall glycemic outcomes. Patients must receive thorough education on correct injection technique, appropriate dose titration based on blood glucose monitoring, and the importance of rotating injection sites. As with all insulin products, careful management is essential to prevent hypoglycemia, which is the most common adverse effect. Regular follow-up with a healthcare provider is crucial to adjust doses and monitor for any adverse effects, ensuring optimal and safe diabetes management.

Uses

• Treatment of Type 1 Diabetes Mellitus
• Management of Type 2 Diabetes Mellitus
• Provides both basal and mealtime insulin coverage
• Aids in achieving target blood glucose levels

Directions For Use

Inject subcutaneously once or twice daily with the main meal(s) as prescribed. Rotate injection sites to prevent lipodystrophy.

Benefits

• Combines basal and rapid-acting insulin in one injection
• Offers flexible dosing schedule (once or twice daily)
• Provides sustained glucose control for over 42 hours
• Effectively manages post-meal glucose spikes
• Simplifies insulin regimen for patients
• Reduces the number of daily injections

Side Effects

• Hypoglycemia (low blood sugar)
• Injection site reactions (pain, redness, swelling)
• Lipodystrophy (fat accumulation or atrophy)
• Weight gain
• Allergic reactions
• Peripheral edema
• Pruritus
• Rash
• Urticaria
• Blurred vision (temporary)
• Diabetic retinopathy worsening (temporary)
• Hypokalemia (low potassium)

Safety Measures

• Alcohol - Alcohol can lower blood sugar and increase the risk of hypoglycemia. Use with caution and monitor glucose levels.
• Pregnancy - Consult a doctor. Insulin requirements may change during pregnancy. Close monitoring is essential.
• Breastfeeding - Generally considered safe, but consult a healthcare provider. Insulin does not pass into breast milk in significant amounts.
• Liver - Use with caution in hepatic impairment; insulin requirements may be altered. Monitor glucose levels closely.
• Kidney - Use with caution in renal impairment; insulin requirements may be altered. Monitor glucose levels closely.
• Lung - No specific contraindications for lung conditions.

Disclaimer

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