About

Sunitinib is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that plays a crucial role in oncology by blocking several key receptors implicated in tumor growth, angiogenesis, and metastatic progression. Its mechanism of action involves inhibiting platelet-derived growth factor receptors (PDGFRα and PDGFRβ), vascular endothelial growth factor receptors (VEGFR1, VEGFR2, and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony-stimulating factor-1 receptor (CSF-1R), and glial cell line-derived neurotrophic factor receptor (RET). By broadly inhibiting these critical signaling pathways, sunitinib effectively disrupts the proliferation and survival of cancer cells and their supporting microenvironment. This leads to significant anti-tumor effects, making it a cornerstone in the treatment of specific advanced cancers where these pathways are dysregulated, improving patient outcomes and disease control.

Uses

Renal cell carcinoma (RCC)
Gastrointestinal stromal tumor (GIST)
Pancreatic neuroendocrine tumors (pNET)
Advanced metastatic RCC

Directions For Use

Take orally once daily with or without food, as prescribed by your oncologist.

Benefits

Inhibits tumor growth
Reduces tumor vascularization
Slows disease progression
Improves progression-free survival
Targets multiple cancer pathways
Oral administration for convenience

Side Effects

Fatigue
Diarrhea
Nausea
Vomiting
Stomatitis
Hand-foot syndrome
Hypertension
Thyroid dysfunction
Skin discoloration
Bleeding events
Cardiac dysfunction
Neutropenia

Safety Measures

Alcohol - Avoid or limit alcohol due to potential for liver toxicity and exacerbation of side effects.
Pregnancy - Contraindicated in pregnancy; use effective contraception during treatment and for a period after.
Breastfeeding - Not recommended; discontinue breastfeeding due to potential harm to the infant.
Liver - Use with caution; monitor liver function tests regularly. Dose adjustments may be needed for severe impairment.
Kidney - Use with caution; monitor renal function. Dose adjustments may be needed for severe impairment.
Lung - Monitor for pulmonary embolism or other lung-related adverse events.

Disclaimer

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