SYNSTIM INJ COMBIPACK 1+1 VIAL

About

SYNSTIM is a recombinant human granulocyte colony-stimulating factor (G-CSF) that regulates the production and release of neutrophils from the bone marrow. It works by binding to specific G-CSF receptors on hematopoietic stem cells and progenitor cells, stimulating their proliferation, differentiation, and functional activation. This leads to a significant increase in the number of neutrophils in the peripheral blood, which are crucial components of the immune system responsible for fighting bacterial and fungal infections. The primary goal of SYNSTIM therapy is to reduce the incidence and duration of neutropenia, a condition characterized by abnormally low levels of neutrophils, often caused by myelosuppressive chemotherapy or other medical conditions.

By boosting neutrophil counts, SYNSTIM helps to prevent serious infections and allows patients to maintain their prescribed chemotherapy regimens, thereby improving treatment outcomes and quality of life. It is a vital supportive care medication in oncology and other fields where bone marrow function is compromised. The combipack likely includes the active drug vial and a diluent or syringe for convenient preparation and administration.

Uses

• Reduction of infection incidence in patients receiving myelosuppressive chemotherapy.
• Mobilization of peripheral blood progenitor cells for autologous or allogeneic transplantation.
• Treatment of severe chronic neutropenia.
• Reduction of neutropenia duration in patients undergoing bone marrow transplantation.

Directions For Use

Administered by subcutaneous injection or intravenous infusion. Follow healthcare provider's instructions for preparation and administration.

Benefits

• Reduces risk of serious infections.
• Shortens duration of chemotherapy-induced neutropenia.
• Enables patients to receive full chemotherapy doses on schedule.
• Supports bone marrow recovery after transplantation.
• Improves quality of life for neutropenic patients.
• Essential supportive care in cancer treatment.

Side Effects

• Bone pain
• Myalgia (muscle pain)
• Fatigue
• Nausea
• Headache
• Injection site reactions
• Splenomegaly (enlarged spleen)
• Thrombocytopenia
• Leukocytosis (high white blood cell count)
• Allergic reactions
• Acute respiratory distress syndrome (rare)
• Glomerulonephritis (rare)

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol may worsen general health or mask symptoms.
• Pregnancy - Use only if clearly needed; potential risks to the fetus are not fully established. Discuss with a doctor.
• Breastfeeding - It is unknown if SYNSTIM is excreted in human milk. Exercise caution; consult a healthcare professional.
• Liver - No specific dose adjustment required for liver impairment, but monitor overall patient condition.
• Kidney - No specific dose adjustment required for renal impairment, but monitor overall patient condition.
• Lung - Monitor for pulmonary adverse reactions, such as interstitial lung disease, especially in patients with pre-existing lung conditions.

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