About
Telmisartan/Amlodipine, known as Telvas AM, is a fixed-dose combination medication used for the treatment of essential hypertension. Telmisartan is an angiotensin II receptor blocker (ARB) that works by blocking the effects of angiotensin II, a potent vasoconstrictor, leading to vasodilation and reduced blood pressure. Amlodipine is a dihydropyridine calcium channel blocker (CCB) that inhibits the influx of calcium ions into vascular smooth muscle cells, causing peripheral vasodilation and reducing systemic vascular resistance. This combination provides a powerful synergistic effect, offering comprehensive and sustained blood pressure control by addressing both the renin-angiotensin system and calcium channels. This often leads to more effective blood pressure reduction than either agent alone, making it a valuable option for patients who require more aggressive blood pressure management or who have not achieved target blood pressure with monotherapy.
Uses
- Treatment of essential hypertension.
- When monotherapy with telmisartan or amlodipine is insufficient.
- To achieve optimal and sustained blood pressure control.
- To reduce the risk of cardiovascular events in hypertensive patients.
Directions For Use
Take orally once daily, with or without food, as directed by your healthcare provider. Swallow the tablet whole.
Benefits
- Provides effective and sustained blood pressure reduction.
- Combines two complementary antihypertensive mechanisms.
- Offers convenient once-daily dosing.
- Reduces the risk of cardiovascular morbidity and mortality.
- Effective in patients requiring more aggressive BP lowering.
- Amlodipine has a long duration of action.
Side Effects
- Dizziness
- Headache
- Peripheral edema (swelling of ankles/feet)
- Fatigue
- Flushing
- Hypotension (low blood pressure)
- Nausea
- Abdominal pain
- Palpitations
- Cough (less common than with ACE inhibitors)
- Somnolence
- Gingival hyperplasia (rare)
Safety Measures
- Alcohol - Alcohol can enhance the hypotensive effects; use with caution and avoid excessive intake.
- Pregnancy - Contraindicated in pregnancy due to potential fetal harm from telmisartan (renal dysfunction, oligohydramnios).
- Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and harm the infant.
- Liver - Use with caution in hepatic impairment; dose adjustment may be necessary, especially for telmisartan and amlodipine.
- Kidney - Use with caution in renal impairment; monitor kidney function and potassium levels regularly.
- Lung - Generally safe for use in patients with lung conditions; no specific pulmonary contraindications.
Disclaimer
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