Trasmab 440mg Injection

About

Trasmab 440mg Injection is a targeted therapy containing Trastuzumab, a recombinant humanized monoclonal antibody that selectively binds to the extracellular domain of the human epidermal growth factor receptor 2 (HER2) protein. Overexpression of HER2 is observed in certain types of cancers, particularly breast cancer and gastric cancer, and is associated with aggressive disease and poor prognosis. By binding to HER2, Trastuzumab inhibits the proliferation of tumor cells that overexpress HER2, leading to cell cycle arrest and apoptosis. It also mediates antibody-dependent cell-mediated cytotoxicity (ADCC), further contributing to its anti-tumor effects. This medication is a cornerstone in the treatment of HER2-positive malignancies, significantly improving patient outcomes when used alone or in combination with chemotherapy. Its specific action minimizes damage to healthy cells, offering a more precise approach to cancer treatment.

Uses

• Treatment of HER2-positive early breast cancer.
• Management of HER2-positive metastatic breast cancer.
• Therapy for HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma.
• Adjuvant therapy after surgery, chemotherapy, and radiation for early breast cancer.

Directions For Use

Administered intravenously by a healthcare professional, typically as an infusion, with dosing and frequency determined by the specific cancer type and patient's weight.

Benefits

• Targeted therapy for HER2-positive cancers.
• Improves survival rates in HER2-positive breast cancer.
• Reduces risk of cancer recurrence.
• Can be used in combination with chemotherapy.
• Specific mechanism of action.
• Established efficacy in clinical trials.

Side Effects

• Fever and chills (infusion reactions)
• Nausea
• Diarrhea
• Headache
• Fatigue
• Rash
• Insomnia
• Muscle pain
• Cardiac dysfunction (e.g., decreased ejection fraction)
• Pulmonary toxicity (rare)
• Hypersensitivity reactions
• Neutropenia

Safety Measures

• Alcohol - No direct interaction, but alcohol should be avoided if it exacerbates side effects or interferes with overall health during cancer treatment.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm; effective contraception is required.
• Breastfeeding - Not recommended during breastfeeding due to potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with pre-existing liver impairment; monitor liver function.
• Kidney - Use with caution in patients with severe renal impairment; monitor kidney function.
• Lung - Use with extreme caution in patients with pre-existing lung conditions or cardiac dysfunction due to risk of pulmonary toxicity.

Disclaimer

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