UNIFOLIN 15 MG TAB. 1X10 TAB.

About

UNIFOLIN 15 MG TAB. contains Leucovorin, also known as folinic acid, which is a reduced form of folic acid that does not require reduction by the enzyme dihydrofolate reductase. This characteristic makes it immediately available to participate in crucial metabolic pathways, particularly those involved in DNA synthesis and repair, and amino acid interconversions. Leucovorin is primarily employed in oncology as a "rescue" agent to mitigate the severe toxic effects of folic acid antagonists, such as high-dose methotrexate, by providing a bypass mechanism for folate metabolism, thereby protecting healthy cells from damage. Additionally, it is utilized to enhance the cytotoxic activity of fluorouracil in the treatment of certain cancers, notably colorectal cancer, by stabilizing the binding of fluorouracil metabolites to thymidylate synthase. Its precise dosing and timing are critical for maximizing therapeutic benefits while minimizing adverse effects in complex chemotherapy regimens.

Uses

• Leucovorin rescue after high-dose methotrexate therapy.
• Potentiation of fluorouracil in colorectal cancer.
• Treatment of megaloblastic anemia due to folate deficiency (less common at 15mg).
• Antidote for other folate antagonist overdoses.

Directions For Use

Take orally as directed by a physician. Dosage and schedule are highly specific to the treatment protocol.

Benefits

• Reduces toxicity of methotrexate.
• Enhances efficacy of fluorouracil.
• Essential for certain chemotherapy regimens.
• Supports normal cell function.
• Available in convenient tablet form.
• Helps manage chemotherapy side effects.

Side Effects

• Allergic reactions (rare)
• Fever
• Rash
• Itching
• Nausea
• Vomiting
• Diarrhea
• Stomatitis (when used with fluorouracil)
• Seizures (rare, with high doses)
• Insomnia
• Agitation
• Depression

Safety Measures

• Alcohol - No specific interaction, but alcohol can interfere with folate metabolism; moderation is advised.
• Pregnancy - Use only if clearly indicated and benefits outweigh risks, especially when used as a rescue agent in chemotherapy.
• Breastfeeding - Excreted in breast milk; consult a physician. Breastfeeding may need to be temporarily discontinued.
• Liver - Use with caution in patients with severe liver impairment; monitor for potential toxicity.
• Kidney - Use with caution in patients with renal impairment, especially when used with methotrexate; dose adjustments may be necessary.
• Lung - No specific contraindications related to lung conditions.

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