PEG-L-ASPATERO 3750IU 5ML PFS

About

PEG-L-ASPATERO 3750IU 5ML PFS, containing Pegaspargase, is a modified form of the enzyme L-asparaginase, primarily used in the treatment of acute lymphoblastic leukemia (ALL). This enzyme works by depleting asparagine, a non-essential amino acid, from the bloodstream. Leukemic cells, unlike normal cells, are often unable to synthesize their own asparagine and are therefore dependent on exogenous sources. By depriving these cancer cells of asparagine, Pegaspargase inhibits protein synthesis and ultimately induces apoptosis (programmed cell death) in the leukemic cells.

The pegylated formulation extends the half-life of the enzyme, allowing for less frequent administration compared to native L-asparaginase, which improves patient convenience and compliance. It is a critical component of multi-agent chemotherapy regimens for ALL in both pediatric and adult patients. Due to its unique mechanism of action, it is highly effective in inducing remission and improving long-term survival rates, particularly in combination with other cytotoxic agents. Close monitoring for potential side effects, including hypersensitivity reactions and pancreatic toxicity, is essential during treatment.

Uses

• Treatment of acute lymphoblastic leukemia (ALL)
• Used in combination with other chemotherapeutic agents
• Induction and consolidation phases of ALL therapy
• Management of ALL in pediatric and adult patients

Directions For Use

Administer intramuscularly or intravenously as a slow infusion, as directed by an oncologist. Follow the prescribed dosing schedule carefully.

Benefits

• Crucial component of ALL treatment regimens
• Extended half-life allows for less frequent dosing
• Effective in inducing remission in leukemic cells
• Targeted action on asparagine-dependent cancer cells
• Improves long-term survival rates in ALL patients
• Reduces the burden of frequent injections

Side Effects

• Hypersensitivity reactions (anaphylaxis)
• Pancreatitis
• Coagulopathy (thrombosis or hemorrhage)
• Hyperglycemia
• Elevated liver enzymes
• Hypertriglyceridemia
• Nausea
• Vomiting
• Fatigue
• Fever
• Skin rash
• Central nervous system toxicity

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to the potential for increased liver and pancreatic strain, which can exacerbate side effects.
• Pregnancy - Contraindicated during pregnancy due to its teratogenic potential. Women of childbearing potential must use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it is excreted in human milk and could cause serious adverse reactions in the infant.
• Liver - Use with extreme caution due to a significant risk of hepatotoxicity. Monitor liver function tests closely and frequently during treatment.
• Kidney - Generally, no dose adjustment is needed for patients with renal impairment. Monitor for any adverse effects.
• Lung - Monitor for hypersensitivity reactions, which can manifest as respiratory distress or bronchospasm. Manage promptly if symptoms occur.

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