Zocitab 500mg Tablet

About

Capecitabine is an oral fluoropyrimidine carbamate that functions as a prodrug, converting into the active cytotoxic agent 5-fluorouracil (5-FU) primarily within tumor cells. This selective activation is facilitated by higher concentrations of the enzyme thymidine phosphorylase, which is often found in various solid tumors. By inhibiting DNA synthesis and cell proliferation, capecitabine effectively targets and destroys cancer cells, making it a crucial component in the treatment of several types of cancer. Its mechanism of action provides a more localized effect, potentially reducing systemic toxicity. The significant advantage of capecitabine lies in its oral administration, offering considerable convenience and improved quality of life for patients undergoing long-term chemotherapy regimens, allowing for treatment outside of a hospital setting while maintaining therapeutic efficacy.

Uses

• Adjuvant treatment of colon cancer.
• Metastatic colorectal cancer.
• Metastatic breast cancer.
• Advanced gastric cancer.

Directions For Use

Take orally with water within 30 minutes after a meal. Follow your doctor's prescribed dosage and schedule.

Benefits

• Oral administration offers convenience.
• Targeted activation in tumor cells.
• Effective against various solid tumors.
• Can be used as monotherapy or in combination.
• Improved quality of life compared to IV chemotherapy.
• Reduces tumor growth and spread.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Stomatitis (mouth sores)
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Fatigue
• Abdominal pain
• Anorexia
• Dermatitis
• Hyperbilirubinemia
• Neutropenia
• Dehydration

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects.
• Pregnancy - Contraindicated; causes fetal harm. Use effective contraception during and for a period after treatment.
• Breastfeeding - Not recommended; unknown if excreted in human milk, but potential for serious adverse reactions in infants.
• Liver - Use with caution in hepatic impairment; monitor liver function closely.
• Kidney - Dose adjustment required in moderate renal impairment; contraindicated in severe renal impairment.
• Lung - Use with caution in patients with pre-existing lung conditions; rare cases of interstitial pneumonitis reported.

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