ZOCRA-4.5

About

Piperacillin/Tazobactam, often branded as Zocra-4.5, is a potent combination antibiotic consisting of an extended-spectrum penicillin (piperacillin) and a beta-lactamase inhibitor (tazobactam). This combination provides broad-spectrum activity against many Gram-positive and Gram-negative aerobic and anaerobic bacteria, including those that produce beta-lactamase enzymes. Tazobactam protects piperacillin from enzymatic degradation, thereby significantly extending its antibacterial spectrum. It is primarily used for severe bacterial infections, often in hospital settings, such as complicated intra-abdominal infections, hospital-acquired and ventilator-associated pneumonia, complicated skin and soft tissue infections, and complicated urinary tract infections. Its robust efficacy makes it a critical agent in managing serious infections, particularly in critically ill patients.

Uses

• Treatment of complicated intra-abdominal infections.
• Management of hospital-acquired and ventilator-associated pneumonia.
• Treatment of complicated skin and soft tissue infections.
• Management of complicated urinary tract infections.

Directions For Use

Administered intravenously by a healthcare professional, typically over 30 minutes, as prescribed by a doctor.

Benefits

• Broad-spectrum antibacterial activity.
• Effective against resistant bacteria (beta-lactamase producers).
• Treats severe and complicated infections.
• Crucial for critically ill patients.
• Penetrates various body tissues effectively.
• Often used as empiric therapy.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Rash
• Headache
• Insomnia
• Constipation
• Elevated liver enzymes
• Thrombocytopenia
• Leukopenia
• Hypokalemia
• Allergic reactions (including anaphylaxis)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects and potentially interact with the medication.
• Pregnancy - Use during pregnancy only if clearly needed and the potential benefits outweigh the risks; consult a doctor.
• Breastfeeding - Excreted in small amounts into breast milk; use with caution and monitor infant for diarrhea or thrush. Consult a doctor.
• Liver - Use with caution in patients with severe liver impairment; monitor liver function tests regularly.
• Kidney - Dose adjustment is essential in patients with renal impairment to prevent drug accumulation and toxicity; monitor kidney function closely.
• Lung - Often used to treat severe lung infections like pneumonia; generally safe, but monitor for allergic reactions.

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