TARGOCID 400 INJ

About

Targocid 400 Injection, containing teicoplanin, is a glycopeptide antibiotic used to treat serious Gram-positive bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA) and enterococci. It works by inhibiting bacterial cell wall synthesis, leading to bacterial death. Teicoplanin is often preferred over vancomycin in certain situations due to its longer half-life, allowing for once-daily dosing after an initial loading regimen, and its lower potential for nephrotoxicity and ototoxicity.

It is effective in treating a range of severe infections including complicated skin and soft tissue infections, bone and joint infections, endocarditis, and peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD). Its intravenous administration ensures systemic distribution to target the infection effectively, making it a valuable option for patients requiring prolonged treatment or those with compromised renal function where other antibiotics might pose higher risks.

Uses

• Treatment of serious infections caused by MRSA.
• Management of endocarditis caused by Gram-positive bacteria.
• Treatment of complicated skin and soft tissue infections.
• Prophylaxis against Gram-positive infections in certain surgical procedures.

Directions For Use

Administer intravenously by slow injection over 3-5 minutes or by infusion over 30 minutes, as prescribed by a doctor.

Benefits

• Effective against multi-drug resistant Gram-positive bacteria (e.g., MRSA).
• Long half-life allows for once-daily dosing.
• Lower risk of nephrotoxicity and ototoxicity compared to vancomycin.
• Suitable for long-term treatment of chronic infections.
• Can be used in patients with renal impairment with dose adjustment.
• Effective in treating severe bone and joint infections.

Side Effects

• Rash
• Pruritus
• Fever
• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Headache
• Injection site reactions
• Increased liver enzymes
• Transient hearing loss (rare)
• Nephrotoxicity (rare, especially with co-administration of other nephrotoxic drugs)

Safety Measures

• Alcohol - No specific interaction with alcohol, but it's generally advisable to avoid alcohol during severe infections.
• Pregnancy - Use only if clearly needed; potential risks should be weighed against the benefits.
• Breastfeeding - Small amounts may pass into breast milk; use with caution and monitor the infant for adverse effects.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests.
• Kidney - Dosage adjustment is necessary in patients with renal impairment due to renal excretion. Monitor kidney function closely.
• Lung - Generally safe for lung conditions, often used to treat severe respiratory tract infections.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.